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Open AccessFeature PaperReview

The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies

College of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London, London UB8 3PH, UK
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Cells 2019, 8(7), 687; https://doi.org/10.3390/cells8070687
Received: 20 May 2019 / Revised: 5 July 2019 / Accepted: 6 July 2019 / Published: 7 July 2019
(This article belongs to the Special Issue Molecular Regulation of Mitosis and Its Role in Disease)
The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining healthy cells and any deviation from this can result in pathological conditions. This review aims at assessing the current understanding of how phosphatases contribute to the remodelling of the nuclear envelope during its disassembling and reformation after cell division and how errors in this process may lead to the development of diseases. View Full-Text
Keywords: nuclear envelope (NE); nuclear pore complex (NPC); nuclear lamina; cyclin dependent kinase (CDK); polo-like kinase (PLK); protein phosphatase; micronuclei (MN) nuclear envelope (NE); nuclear pore complex (NPC); nuclear lamina; cyclin dependent kinase (CDK); polo-like kinase (PLK); protein phosphatase; micronuclei (MN)
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Huguet, F.; Flynn, S.; Vagnarelli, P. The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies. Cells 2019, 8, 687.

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