Next Article in Journal
The Role of Phosphatases in Nuclear Envelope Disassembly and Reassembly and Their Relevance to Pathologies
Previous Article in Journal
Advanced Molecular Knowledge of Therapeutic Drugs and Natural Products Focusing on Inflammatory Cytokines in Asthma
Previous Article in Special Issue
Mitochondrial DNA Variants and Common Diseases: A Mathematical Model for the Diversity of Age-Related mtDNA Mutations
Open AccessEditor’s ChoiceReview

Mitochondrial Homeostasis and Cellular Senescence

1
Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
2
Department of Anatomy, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
3
Nursing School, National and Kapodistrian University of Athens, 123 Papadiamantopoulou Str., 11527 Athens, Greece
4
Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST Newcastle, UK
5
Second Department of Orthopaedics, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
6
Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester MP13 9PL, UK
7
Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Str., 11527 Athens, Greece
8
Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece
*
Author to whom correspondence should be addressed.
Cells 2019, 8(7), 686; https://doi.org/10.3390/cells8070686
Received: 15 June 2019 / Revised: 2 July 2019 / Accepted: 5 July 2019 / Published: 6 July 2019
(This article belongs to the Special Issue Mitochondrial Genetics)
Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction. View Full-Text
Keywords: cellular senescence; mitochondria; mitostasis; mitochondrial dynamics cellular senescence; mitochondria; mitostasis; mitochondrial dynamics
Show Figures

Figure 1

MDPI and ACS Style

Vasileiou, P.V.; Evangelou, K.; Vlasis, K.; Fildisis, G.; Panayiotidis, M.I.; Chronopoulos, E.; Passias, P.-G.; Kouloukoussa, M.; Gorgoulis, V.G.; Havaki, S. Mitochondrial Homeostasis and Cellular Senescence. Cells 2019, 8, 686.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop