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A Review of Macrophage MicroRNAs’ Role in Human Asthma

1
Department of Hematology, Iuliu Haţieganu University of Medicine and Pharmacy, 400124 Cluj-Napoca, Romania
2
Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Haţieganu University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
3
Department of Hematology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
4
National Heart and Lung Institute, Imperial College London, London W2 1PG, UK
5
Department of Hematology, Ion Chiricuta Oncology Institute, 400010 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Cells 2019, 8(5), 420; https://doi.org/10.3390/cells8050420
Received: 1 April 2019 / Revised: 1 May 2019 / Accepted: 7 May 2019 / Published: 8 May 2019
(This article belongs to the Special Issue The Molecular and Cellular Basis for Allergies & Asthma)
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Abstract

There is an imbalance in asthma between classically activated macrophages (M1 cells) and alternatively activated macrophages (M2 cells) in favor of the latter. MicroRNAs (miRNAs) play a critical role in regulating macrophage proliferation and differentiation and control the balance of M1 and M2 macrophage polarization, thereby controlling immune responses. Here we review the current published data concerning miRNAs with known correlation to a specific human macrophage phenotype and polarization, and their association with adult asthma. MiRNA-targeted therapy is still in the initial stages, but clinical trials are under recruitment or currently running for some miRNAs in other diseases. Regulating miRNA expression via their upregulation or downregulation could show potential as a novel therapy for improving treatment efficacy in asthma. View Full-Text
Keywords: asthma; molecular asthma; macrophages; microRNA asthma; molecular asthma; macrophages; microRNA
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Feketea, G.; Bocsan, C.I.; Popescu, C.; Gaman, M.; Stanciu, L.A.; Zdrenghea, M.T. A Review of Macrophage MicroRNAs’ Role in Human Asthma. Cells 2019, 8, 420.

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