Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases
AbstractModulation of telomerase maintenance by gene therapy must meet two polarizing requirements to achieve different therapeutic outcomes: Anti-aging/regenerative applications require upregulation, while anticancer applications necessitate suppression of various genes integral to telomere maintenance (e.g., telomerase, telomerase RNA components, and shelterin complex). Patients suffering from aging-associated illnesses often exhibit telomere attrition, which promotes chromosomal instability and cellular senescence, thus requiring the transfer of telomere maintenance-related genes to improve patient outcomes. However, reactivation and overexpression of telomerase are observed in 85% of cancer patients; this process is integral to cancer immortality. Thus, telomere-associated genes in the scope of cancer gene therapy must be inactivated or inhibited to induce anticancer effects. These contradicting requirements for achieving different therapeutic outcomes mean that any vector-mediated upregulation of telomere-associated genes must be accompanied by rigorous evaluation of potential oncogenesis. Thus, this review aims to discuss how telomere-associated genes are being targeted or utilized in various gene therapy applications and provides some insight into currently available safety hazard assessments. View Full-Text
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Hong, J.; Yun, C.-O. Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases. Cells 2019, 8, 392.
Hong J, Yun C-O. Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases. Cells. 2019; 8(5):392.Chicago/Turabian Style
Hong, JinWoo; Yun, Chae-Ok. 2019. "Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases." Cells 8, no. 5: 392.
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