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The Resolution of Intestinal Inflammation: The Peace-Keeper’s Perspective

1
Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
2
Department of Systems Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Cells 2019, 8(4), 344; https://doi.org/10.3390/cells8040344
Received: 15 March 2019 / Revised: 8 April 2019 / Accepted: 10 April 2019 / Published: 11 April 2019
The uncontrolled activation of the immune system toward antigens contained in the gut lumen in genetically predisposed subjects is believed to be the leading cause of inflammatory bowel disease (IBD). Two not mutually exclusive hypotheses can explain the pathogenic process leading to IBD. The first and mostly explored hypothesis states that the loss of tolerance toward gut microbiota antigens generates an aberrant inflammatory response that is perpetuated by continuous and unavoidable exposure to the triggering antigens. However, the discovery that the resolution of inflammation is not the mere consequence of clearing inflammatory triggers and diluting pro-inflammatory factors, but rather an active process in which molecular and cellular elements are involved, implies that a defect in the pro-resolving mechanisms might cause chronic inflammation in different immune-mediated diseases, including IBD. Here we review data on pro-resolving and counter-regulatory mechanisms involved in the resolution of inflammation, aiming to identify their possible involvement in the pathogenesis of IBD. View Full-Text
Keywords: colitis; resolution; immunosuppression; counter-regulatory mechanisms colitis; resolution; immunosuppression; counter-regulatory mechanisms
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MDPI and ACS Style

Onali, S.; Favale, A.; Fantini, M.C. The Resolution of Intestinal Inflammation: The Peace-Keeper’s Perspective. Cells 2019, 8, 344. https://doi.org/10.3390/cells8040344

AMA Style

Onali S, Favale A, Fantini MC. The Resolution of Intestinal Inflammation: The Peace-Keeper’s Perspective. Cells. 2019; 8(4):344. https://doi.org/10.3390/cells8040344

Chicago/Turabian Style

Onali, Sara; Favale, Agnese; Fantini, Massimo C 2019. "The Resolution of Intestinal Inflammation: The Peace-Keeper’s Perspective" Cells 8, no. 4: 344. https://doi.org/10.3390/cells8040344

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