Next Article in Journal
The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability
Next Article in Special Issue
YAP, ΔNp63, and β-Catenin Signaling Pathways Are Involved in the Modulation of Corneal Epithelial Stem Cell Phenotype Induced by Substrate Stiffness
Previous Article in Journal
The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene
Previous Article in Special Issue
Signals from the Niche: Insights into the Role of IGF-1 and IL-6 in Modulating Skeletal Muscle Fibrosis
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Cells 2019, 8(3), 245; https://doi.org/10.3390/cells8030245

Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review

1
Department of Medical Biochemistry, Oslo University Hospital, Ullevål, 0450 Oslo, Norway
2
Center for Eye Research, Department of Ophthalmology, Oslo University Hospital, Ullevål, 0450 Oslo, Norway
3
Department of Plastic and Reconstructive Surgery, Oslo University Hospital, 0450 Oslo, Norway
4
Institute of Oral Biology, Faculty of Dentistry, University of Oslo, 0318 Oslo, Norway
5
Department of Maxillofacial Surgery, Oslo University Hospital, 0450 Oslo, Norway
6
Department of Ophthalmology, Vestre Viken Hospital Trust, 3019 Drammen, Norway
7
Department of Ophthalmology, Stavanger University Hospital, 4011 Stavanger, Norway
8
Department of Clinical Medicine, Faculty of Medicine, University of Bergen, 5020 Bergen, Norway
9
Department of Ophthalmology, Sørlandet Hospital Arendal, 4604 Arendal, Norway
10
National Centre for Optics, Vision and Eye Care, Faculty of Health Sciences, University of South Eastern Norway, 3603 Kongsberg, Norway
*
Author to whom correspondence should be addressed.
Received: 9 February 2019 / Revised: 8 March 2019 / Accepted: 11 March 2019 / Published: 14 March 2019
(This article belongs to the Special Issue Tissue Regeneration and Fibrosis)
  |  
PDF [2191 KB, uploaded 23 March 2019]
  |  

Abstract

Hyaluronan (HA), also termed hyaluronic acid or hyaluronate, is a major component of the extracellular matrix. This non-sulfated glycosaminoglycan plays a key role in cell proliferation, growth, survival, polarization, and differentiation. The diverse biological roles of HA are linked to the combination of HA’s physicochemical properties and HA-binding proteins. These unique characteristics have encouraged the application of HA-based hydrogel scaffolds for stem cell-based therapy, a successful method in the treatment of limbal stem cell deficiency (LSCD). This condition occurs following direct damage to limbal stem cells and/or changes in the limbal stem cell niche microenvironment due to intrinsic and extrinsic insults. This paper reviews the physical properties, synthesis, and degradation of HA. In addition, the interaction of HA with other extracellular matrix (ECM) components and receptor proteins are discussed. Finally, studies employing HA-based hydrogel scaffolds in the treatment of LSCD are reviewed. View Full-Text
Keywords: hyaluronic acid; hyaluronan; hydrogel scaffolds; stem cell-based therapy; transplantation; limbal stem cell deficiency (LSCD) hyaluronic acid; hyaluronan; hydrogel scaffolds; stem cell-based therapy; transplantation; limbal stem cell deficiency (LSCD)
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Yazdani, M.; Shahdadfar, A.; Jackson, C.J.; Utheim, T.P. Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review. Cells 2019, 8, 245.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top