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Microbiome, Parkinson’s Disease and Molecular Mimicry

1
Department of Pharmacy, University of Pisa, via Bonanno 6, 56126 Pisa, Italy
2
[email protected] Laboratory, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
Cells 2019, 8(3), 222; https://doi.org/10.3390/cells8030222
Received: 31 January 2019 / Revised: 4 March 2019 / Accepted: 5 March 2019 / Published: 7 March 2019
(This article belongs to the Special Issue The Molecular and Cellular Basis for Parkinson's Disease)
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PDF [378 KB, uploaded 8 March 2019]

Abstract

Parkinson’s Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external environment, including the olfactory bulbs and the enteric nervous system. This, combined with the ability of alpha-synuclein (αS) to propagate in a prion-like manner, has supported the hypothesis that the resident microbial community, commonly referred to as microbiota, might play a causative role in the development of PD. In this article, we will be reviewing current knowledge on the importance of the microbiota in PD pathology, concentrating our investigation on mechanisms of microbiota-host interactions that might become harmful and favor the onset of PD. Such processes, which include the secretion of bacterial amyloid proteins or other metabolites, may influence the aggregation propensity of αS directly or indirectly, for example by favoring a pro-inflammatory environment in the gut. Thus, while the development of PD has not yet being associated with a unique microbial species, more data will be necessary to examine potential harmful interactions between the microbiota and the host, and to understand their relevance in PD pathogenesis. View Full-Text
Keywords: Parkinson’s disease; microbiota; molecular mimicry; microbiome; alpha-synuclein; curli; gut-brain axis; neurodegeneration Parkinson’s disease; microbiota; molecular mimicry; microbiome; alpha-synuclein; curli; gut-brain axis; neurodegeneration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Miraglia, F.; Colla, E. Microbiome, Parkinson’s Disease and Molecular Mimicry. Cells 2019, 8, 222.

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