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Cells 2019, 8(2), 141; https://doi.org/10.3390/cells8020141

Cardiac Autophagy in Sepsis

1
Departments of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
2
Department of Developmental Cell Biology, School of Life Sciences, China Medical University, 77 Puhe Road, Shenbei New District, Shenyang 110122, China
*
Author to whom correspondence should be addressed.
Received: 27 December 2018 / Revised: 2 February 2019 / Accepted: 5 February 2019 / Published: 10 February 2019
(This article belongs to the Special Issue Autophagy in Tissue Injury and Homeostasis)
Full-Text   |   PDF [298 KB, uploaded 19 February 2019]   |   Review Reports

Abstract

Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypotheses of how autophagy changes in the heart during sepsis and the underlying mechanisms. Recent investigations suggest that specific activation of autophagy initiation factor Beclin-1 has a potential to protect cardiac mitochondria, attenuate inflammation, and improve cardiac function in sepsis. Accordingly, pharmacological interventions targeting this pathway have a potential to become an effective approach to control sepsis outcomes. The role of autophagy during sepsis pathogenesis has been under intensive investigation in recent years. It is expected that developing therapeutic approaches with specificities targeting at autophagy regulatory factors may provide new opportunities to alleviate organ dysfunction caused by maladaptive autophagy during sepsis. View Full-Text
Keywords: Beclin-1; autophagy; mitophagy; cardiac dysfunction; sepsis; endotoxemia Beclin-1; autophagy; mitophagy; cardiac dysfunction; sepsis; endotoxemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sun, Y.; Cai, Y.; Zang, Q.S. Cardiac Autophagy in Sepsis. Cells 2019, 8, 141.

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