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Cells 2019, 8(2), 140; https://doi.org/10.3390/cells8020140

Immune Profiling and Precision Medicine in Systemic Lupus Erythematosus

Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 113-8655 Tokyo, Japan
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Received: 28 December 2018 / Revised: 24 January 2019 / Accepted: 9 February 2019 / Published: 10 February 2019
(This article belongs to the Special Issue The Molecular and Cellular Basis for Lupus)
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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disorder with a wide range of clinical symptoms. Enormous progress has been made in the immunological and genetic understanding of SLE. However, the biology of disease heterogeneity in SLE has remained largely unexplored. Human immune profiling studies, helped by recent technological advances especially in single-cell and “omics” analyses, are now shedding light on the cellular and molecular basis of clinical symptoms and disease flares in individual patients. Peripheral blood immunophenotyping analysis with flow cytometry or mass cytometry are identifying responsible cell subsets and markers characteristic of disease heterogeneity. Transcriptome analysis is discovering molecular networks responsible for disease activity, disease subtype and future relapse. In this review, we summarize recent advances in the immune profiling analysis of SLE patients and discuss how they will be used for future precision medicine. View Full-Text
Keywords: systemic lupus erythematosus; immune profiling; single-cell analysis; transcriptome; precision medicine systemic lupus erythematosus; immune profiling; single-cell analysis; transcriptome; precision medicine
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Nagafuchi, Y.; Shoda, H.; Fujio, K. Immune Profiling and Precision Medicine in Systemic Lupus Erythematosus. Cells 2019, 8, 140.

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