Next Article in Journal
Regulation of Survivin Isoform Expression by GLI Proteins in Ovarian Cancer
Next Article in Special Issue
Immune Profiling and Precision Medicine in Systemic Lupus Erythematosus
Previous Article in Journal
Extracellular Matrix and Fibrocyte Accumulation in BALB/c Mouse Lung upon Transient Overexpression of Oncostatin M
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview

Epigenetically Altered T Cells Contribute to Lupus Flares

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48103-2200, USA
Cells 2019, 8(2), 127; https://doi.org/10.3390/cells8020127
Received: 8 January 2019 / Revised: 26 January 2019 / Accepted: 2 February 2019 / Published: 5 February 2019
(This article belongs to the Special Issue The Molecular and Cellular Basis for Lupus)
  |  
PDF [1147 KB, uploaded 5 February 2019]
  |  

Abstract

Lupus flares when genetically predisposed people encounter exogenous agents such as infections and sun exposure and drugs such as procainamide and hydralazine, but the mechanisms by which these agents trigger the flares has been unclear. Current evidence indicates that procainamide and hydralazine, as well as inflammation caused by the environmental agents, can cause overexpression of genes normally silenced by DNA methylation in CD4+ T cells, converting them into autoreactive, proinflammatory cytotoxic cells that are sufficient to cause lupus in mice, and similar cells are found in patients with active lupus. More recent studies demonstrate that these cells comprise a distinct CD4+ T cell subset, making it a therapeutic target for the treatment of lupus flares. Transcriptional analyses of this subset reveal proteins uniquely expressed by this subset, which may serve as therapeutic to deplete these cells, treating lupus flares. View Full-Text
Keywords: lupus; environment; epigenetics; DNA methylation lupus; environment; epigenetics; DNA methylation
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Richardson, B. Epigenetically Altered T Cells Contribute to Lupus Flares. Cells 2019, 8, 127.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top