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Open AccessReview

Wnt Signalling in Acute Myeloid Leukaemia

1
Department of Experimental Oncology, Istituto Europeo di Oncologia IRCCS, Via Adamello 16, 20 139 Milan, Italy
2
Department of Oncology and Hemato-Oncology, University of Milan, Via Festa del Perdono 7, 20 122 Milan, Italy
*
Author to whom correspondence should be addressed.
Cells 2019, 8(11), 1403; https://doi.org/10.3390/cells8111403
Received: 23 August 2019 / Revised: 31 October 2019 / Accepted: 6 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Wnt Signaling in Health and Diseases)
Acute myeloid leukaemia (AML) is a group of malignant diseases of the haematopoietic system. AML occurs as the result of mutations in haematopoietic stem/progenitor cells, which upregulate Wnt signalling through a variety of mechanisms. Other mechanisms of Wnt activation in AML have been described such as Wnt antagonist inactivation through promoter methylation. Wnt signalling is necessary for the maintenance of leukaemic stem cells. Several molecules involved in or modulating Wnt signalling have a prognostic value in AML. These include: β-catenin, LEF-1, phosphorylated-GSK3β, PSMD2, PPARD, XPNPEP, sFRP2, RUNX1, AXIN2, PCDH17, CXXC5, LLGL1 and PTK7. Targeting Wnt signalling for tumour eradication is an approach that is being explored in haematological and solid tumours. A number of preclinical studies confirms its feasibility, albeit, so far no reliable clinical trial data are available to prove its utility and efficacy. View Full-Text
Keywords: acute myeloid leukaemia; Wnt signalling; prognosis; treatment acute myeloid leukaemia; Wnt signalling; prognosis; treatment
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MDPI and ACS Style

Gruszka, A.M.; Valli, D.; Alcalay, M. Wnt Signalling in Acute Myeloid Leukaemia. Cells 2019, 8, 1403.

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