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Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy

1
Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
2
Interdipartimental University Center of Research “Adaptation and Regeneration of Tissues and Organs-(ARTO)”, University of Brescia, 25123 Brescia, Italy
3
ANZAC Research Institute, Concord Hospital, NSW 2139 Sydney, Australia
4
Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna-IZSLER, 25124 Brescia, Italy
5
Instituto de Investigaciones Biomedicas “Alberto Sols” (CSIC-UAM), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 12 November 2018 / Revised: 17 December 2018 / Accepted: 19 December 2018 / Published: 21 December 2018
(This article belongs to the Special Issue Cellular Stress Response in Health and Disease)
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Abstract

The interplay of mitochondria with the endoplasmic reticulum and their connections, called mitochondria-ER contacts (MERCs) or mitochondria-associated ER membranes (MAMs), are crucial hubs in cellular stress. These sites are essential for the passage of calcium ions, reactive oxygen species delivery, the sorting of lipids in whole-body metabolism. In this perspective article, we focus on microscopic evidences of the pivotal role of MERCs/MAMs and their changes in metabolic diseases, like obesity, diabetes, and neurodegeneration. View Full-Text
Keywords: mitochondria; endoplasmic reticulum; MERCs; MAMs; obesity; neurodegenerative diseases; microscopy mitochondria; endoplasmic reticulum; MERCs; MAMs; obesity; neurodegenerative diseases; microscopy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Stacchiotti, A.; Favero, G.; Lavazza, A.; Garcia-Gomez, R.; Monsalve, M.; Rezzani, R. Perspective: Mitochondria-ER Contacts in Metabolic Cellular Stress Assessed by Microscopy. Cells 2019, 8, 5.

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