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Cells 2019, 8(1), 33; https://doi.org/10.3390/cells8010033

Preventive Effect of Spontaneous Physical Activity on the Gut-Adipose Tissue in a Mouse Model That Mimics Crohn’s Disease Susceptibility

1
Laboratoire des Adaptations Métaboliques à l’Exercice en conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne, F-63000 Clermont-Ferrand, France
2
Laboratoire Microbes Intestin Inflammation et Susceptibilité de l’Hôte (M2iSH), Université Clermont Auvergne, Inserm U1071, M2iSH, USC-INRA 2018, F-63000 Clermont-Ferrand, France
3
Service d’Hépato-Gastro Entérologie, 3iHP, CHU, F-63000 Clermont-Ferrand, France
4
Service de chirurgie digestive, CHU, F-63000 Clermont-Ferrand, France
5
Department of Bacteriology, CHU, F-63000 Clermont-Ferrand, France
6
UNH, Unité de Nutrition Humaine, Université Clermont Auvergne, INRA, CRNH Auvergne, F-63000 Clermont-Ferrand, France
7
Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne, CNRS, F-63000 Clermont-Ferrand, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 30 November 2018 / Revised: 23 December 2018 / Accepted: 3 January 2019 / Published: 9 January 2019
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Abstract

Crohn’s disease is characterized by abnormal ileal colonization by adherent-invasive E. coli (AIEC) and expansion of mesenteric adipose tissue. This study assessed the preventive effect of spontaneous physical activity (PA) on the gut-adipose tissue in a mouse model that mimics Crohn’s disease susceptibility. Thirty-five CEABAC10 male mice performed spontaneous PA (wheel group; n = 24) or not (controls; n = 11) for 12 weeks. At week 12, mice were orally challenged with the AIEC LF82 strain for 6 days. Body composition, glycaemic control, intestinal permeability, gut microbiota composition, and fecal short-chain fatty acids were assessed in both groups. Animals were fed a high fat/high sugar diet throughout the study. After exposure to AIEC, mesenteric adipose tissue weight was lower in the wheel group. Tight junction proteins expression increased with spontaneous PA, whereas systemic lipopolysaccharides were negatively correlated with the covered distance. Bifidobacterium and Lactobacillus decreased in controls, whereas Oscillospira and Ruminococcus increased in the wheel group. Fecal propionate and butyrate were also higher in the wheel group. In conclusion, spontaneous physical activity promotes healthy gut microbiota composition changes and increases short-chain fatty acids in CEABAC10 mice fed a Western diet and exposed to AIEC to mimic Crohn’s disease. View Full-Text
Keywords: physical activity; mesenteric adipose tissue; Crohn’s disease physical activity; mesenteric adipose tissue; Crohn’s disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Maillard, F.; Vazeille, E.; Sauvanet, P.; Sirvent, P.; Bonnet, R.; Combaret, L.; Chausse, P.; Chevarin, C.; Otero, Y.F.; Delcros, G.; Chavanelle, V.; Boisseau, N.; Barnich, N. Preventive Effect of Spontaneous Physical Activity on the Gut-Adipose Tissue in a Mouse Model That Mimics Crohn’s Disease Susceptibility. Cells 2019, 8, 33.

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