Next Article in Journal
Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies
Next Article in Special Issue
Mood Disorders, Accelerated Aging, and Inflammation: Is the Link Hidden in Telomeres?
Previous Article in Journal
The Potential of Different Origin Stem Cells in Modulating Oral Bone Regeneration Processes
Previous Article in Special Issue
Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest
Open AccessReview

Bring It to an End: Does Telomeres Size Matter?

Aix Marseille Univ, MMG, Marseille Medical Genetics U1251, 13385 Marseille, France
*
Author to whom correspondence should be addressed.
Cells 2019, 8(1), 30; https://doi.org/10.3390/cells8010030
Received: 20 December 2018 / Revised: 1 January 2019 / Accepted: 4 January 2019 / Published: 8 January 2019
(This article belongs to the Special Issue The Role of Telomere Biology in Aging and Human Disease)
Telomeres are unique nucleoprotein structures. Found at the edge of each chromosome, their main purpose is to mask DNA ends from the DNA-repair machinery by formation of protective loops. Through life and cell divisions, telomeres shorten and bring cells closer to either cell proliferation crisis or senescence. Beyond this mitotic clock role attributed to the need for telomere to be maintained over a critical length, the very tip of our DNA has been shown to impact transcription by position effect. TPE and a long-reach counterpart, TPE-OLD, are mechanisms recently described in human biology. Still in infancy, the mechanism of action of these processes and their respective genome wide impact remain to be resolved. In this review, we will discuss recent findings on telomere dynamics, TPE, TPE-OLD, and lessons learnt from model organisms. View Full-Text
Keywords: telomere; TPE; TPE-OLD; TERRA; aging telomere; TPE; TPE-OLD; TERRA; aging
Show Figures

Graphical abstract

MDPI and ACS Style

Laberthonnière, C.; Magdinier, F.; Robin, J.D. Bring It to an End: Does Telomeres Size Matter? Cells 2019, 8, 30.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop