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The Potential of Different Origin Stem Cells in Modulating Oral Bone Regeneration Processes

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Prosthetics and Dental Materials, Faculty of Dental Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania
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Stomestet Stomatology Clinic, Calea Manastur 68A Street, 400658 Cluj-Napoca, Romania; [email protected]
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MEDFUTURE—Research Center for Advanced Medicine, “Iuliu-Hatieganu” University of Medicine and Pharmacy, Marinescu 23 Street, 400337 Cluj-Napoca, Romania
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Research Center for Functional Genomics, Biomedicine and Translational Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Marinescu 23 Street, 400337 Cluj-Napoca, Romania
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Department of Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta”, Republicii 34-36 Street, 400015 Cluj-Napoca, Romania
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Author to whom correspondence should be addressed.
Cells 2019, 8(1), 29; https://doi.org/10.3390/cells8010029
Received: 8 December 2018 / Revised: 22 December 2018 / Accepted: 2 January 2019 / Published: 8 January 2019
(This article belongs to the Section Stem Cells)
Tissue engineering has gained much momentum since the implementation of stem cell isolation and manipulation for regenerative purposes. Despite significant technical improvements, researchers still have to decide which strategy (which type of stem cell) is the most suitable for their specific purpose. Therefore, this short review discusses the advantages and disadvantages of the three main categories of stem cells: embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells in the context of bone regeneration for dentistry-associated conditions. Importantly, when deciding upon the right strategy, the selection needs to be made in concordance with the morbidity and the life-threatening level of the condition in discussion. Therefore, even when a specific type of stem cell holds several advantages over others, their availability, invasiveness of the collection method and ethical standards become deciding parameters. View Full-Text
Keywords: dentistry; regenerative medicine; stem cells; ESCs; MSCs; iPSCs dentistry; regenerative medicine; stem cells; ESCs; MSCs; iPSCs
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Buduru, S.D.; Gulei, D.; Zimta, A.-A.; Tigu, A.B.; Cenariu, D.; Berindan-Neagoe, I. The Potential of Different Origin Stem Cells in Modulating Oral Bone Regeneration Processes. Cells 2019, 8, 29.

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