Next Article in Journal
Mitochondrial Quality Control in COPD and IPF
Next Article in Special Issue
New Insights into the Occurrence of Matrix Metalloproteases -2 and -9 in a Cohort of Breast Cancer Patients and Proteomic Correlations
Previous Article in Journal
Vitamin B6 and Its Role in Cell Metabolism and Physiology
Previous Article in Special Issue
Sub-Cellular Localization of Metalloproteinases in Megakaryocytes
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessFeature PaperReview
Cells 2018, 7(8), 85;

Coagulation, Microenvironment and Liver Fibrosis

Medicina Interna, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Donato, Università Degli Studi di Milano, 20097 San Donato Milanese (MI), Italy
Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, UOC Medicina Generale-Emostasi e Trombosi, 20122 Milano, Italy
Dipartimento di Scienze biomediche per la Salute, Università degli Studi di Milano, 20122 Milano, Italy
A. M. and A. Migliavacca per lo studio delle Malattie del Fegato, 20122 Milano, Italy
Author to whom correspondence should be addressed.
Received: 10 June 2018 / Revised: 19 July 2018 / Accepted: 20 July 2018 / Published: 24 July 2018
(This article belongs to the Special Issue Extracellular Matrix Remodeling)
Full-Text   |   PDF [1037 KB, uploaded 24 July 2018]   |  


Fibrosis is the main consequence of any kind of chronic liver damage. Coagulation and thrombin generation are crucial in the physiological response to tissue injury; however, the inappropriate and uncontrolled activation of coagulation cascade may lead to fibrosis development due to the involvement of several cellular types and biochemical pathways in response to thrombin generation. In the liver, hepatic stellate cells and sinusoidal endothelial cells orchestrate fibrogenic response to chronic damage. Thrombin interacts with these cytotypes mainly through protease-activated receptors (PARs), which are expressed by endothelium, platelets and hepatic stellate cells. This review focuses on the impact of coagulation in liver fibrogenesis, describes receptors and pathways involved and explores the potential antifibrotic properties of drugs active in hemostasis in studies with cells, animal models of liver damage and humans. View Full-Text
Keywords: thrombin; protease-activated receptors; endothelial dysfunction; von Willebrand factor; hepatitis; cirrhosis; anticoagulation thrombin; protease-activated receptors; endothelial dysfunction; von Willebrand factor; hepatitis; cirrhosis; anticoagulation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Bitto, N.; Liguori, E.; Mura, V.L. Coagulation, Microenvironment and Liver Fibrosis. Cells 2018, 7, 85.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top