Next Article in Journal
GABAB Receptors Augment TRPC3-Mediated Slow Excitatory Postsynaptic Current to Regulate Cerebellar Purkinje Neuron Response to Type-1 Metabotropic Glutamate Receptor Activation
Next Article in Special Issue
MicroRNAs and Osteoarthritis
Previous Article in Journal
Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose
Previous Article in Special Issue
Coagulation, Microenvironment and Liver Fibrosis
Open AccessFeature PaperArticle

New Insights into the Occurrence of Matrix Metalloproteases -2 and -9 in a Cohort of Breast Cancer Patients and Proteomic Correlations

Centro di Oncobiologia Sperimentale, Università di Palermo, 90146 Palermo, Italy
La Maddalena Hospital, 90146 Palermo, Italy
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università di Palermo, 90100 Palermo, Italy
Authors to whom correspondence should be addressed.
Cells 2018, 7(8), 89;
Received: 8 June 2018 / Revised: 19 July 2018 / Accepted: 24 July 2018 / Published: 28 July 2018
(This article belongs to the Special Issue Extracellular Matrix Remodeling)
Matrix metalloproteases (MMPs) are a family of well-known enzymes which operate prevalently in the extracellular domain, where they fulfil the function of remodeling the extracellular matrix (ECM). Within the 26 family members, encoded by 24 genes in humans, MMP-2 and MMP-9 have been regarded as primarily responsible for the basement membrane and peri-cellular ECM rearrangement. In cases of infiltrating carcinomas, which arise from the epithelial tissues of a gland or of an internal organ, a marked alteration of the expression and the activity levels of both MMPs is known to occur. The present investigation represents the continuation and upgrading of our previous studies, now focusing on the occurrence and intensity levels of MMP-2 and -9 and their proteomic correlations in a cohort of 80 breast cancer surgical tissues. View Full-Text
Keywords: matrix metalloproteases; breast cancer; proteomics matrix metalloproteases; breast cancer; proteomics
Show Figures

Figure 1

MDPI and ACS Style

Di Cara, G.; Marabeti, M.R.; Musso, R.; Riili, I.; Cancemi, P.; Pucci Minafra, I. New Insights into the Occurrence of Matrix Metalloproteases -2 and -9 in a Cohort of Breast Cancer Patients and Proteomic Correlations. Cells 2018, 7, 89.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop