Next Article in Journal
Revisiting Centrioles in Nematodes—Historic Findings and Current Topics
Next Article in Special Issue
MicroRNAs in Cardiac Autophagy: Small Molecules and Big Role
Previous Article in Journal
CEP55 Promotes Cell Motility via JAK2–STAT3–MMPs Cascade in Hepatocellular Carcinoma
Previous Article in Special Issue
The Role of Extracellular Vesicles in Cancer: Cargo, Function, and Therapeutic Implications
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Cells 2018, 7(8), 100;

Predicting MicroRNA Mediated Gene Regulation between Human and Viruses

The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210023, China
These authors contributed equally to this work as first authors.
Authors to whom correspondence should be addressed.
Received: 26 June 2018 / Revised: 2 August 2018 / Accepted: 6 August 2018 / Published: 8 August 2018
(This article belongs to the Special Issue Regulatory microRNA)
Full-Text   |   PDF [683 KB, uploaded 8 August 2018]   |  


MicroRNAs (miRNAs) mediate various biological processes by actively fine-tuning gene expression at the post-transcriptional level. With the identification of numerous human and viral miRNAs, growing evidence has indicated a common role of miRNAs in mediating the interactions between humans and viruses. However, there is only limited information about Cross-Kingdom miRNA target sites from studies. To facilitate an extensive investigation on the interplay among the gene regulatory networks of humans and viruses, we designed a prediction pipeline, mirTarP, that is suitable for miRNA target screening on the genome scale. By applying mirTarP, we constructed the database mirTar, which is a comprehensive miRNA target repository of bidirectional interspecies regulation between viruses and humans. To provide convenient downloading for users from both the molecular biology field and medical field, mirTar classifies viruses according to “ICTV viral category” and the “medical microbiology classification” on the web page. The mirTar database and mirTarP tool are freely available online. View Full-Text
Keywords: miRNA; virus; host; Cross-Kingdom; target prediction miRNA; virus; host; Cross-Kingdom; target prediction

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Shu, X.; Zang, X.; Liu, X.; Yang, J.; Wang, J. Predicting MicroRNA Mediated Gene Regulation between Human and Viruses. Cells 2018, 7, 100.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top