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Aquaporins and Their Regulation after Spinal Cord Injury

Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK
Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, UK
School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Author to whom correspondence should be addressed.
Cells 2018, 7(10), 174;
Received: 20 September 2018 / Revised: 13 October 2018 / Accepted: 15 October 2018 / Published: 18 October 2018
(This article belongs to the Special Issue Aquaporins)
After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema. View Full-Text
Keywords: spinal cord injury; edema; aquaporin; water channel spinal cord injury; edema; aquaporin; water channel
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Halsey, A.M.; Conner, A.C.; Bill, R.M.; Logan, A.; Ahmed, Z. Aquaporins and Their Regulation after Spinal Cord Injury. Cells 2018, 7, 174.

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