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Cells 2018, 7(10), 156;

The Role of Hydrogen Peroxide in Redox-Dependent Signaling: Homeostatic and Pathological Responses in Mammalian Cells

School of Medicine and Surgery, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy
Current address: Department of Biology, University of Pisa,
Author to whom correspondence should be addressed.
Received: 2 September 2018 / Revised: 29 September 2018 / Accepted: 3 October 2018 / Published: 4 October 2018
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Hydrogen peroxide (H2O2) is an important metabolite involved in most of the redox metabolism reactions and processes of the cells. H2O2 is recognized as one of the main molecules in the sensing, modulation and signaling of redox metabolism, and it is acting as a second messenger together with hydrogen sulfide (H2S) and nitric oxide (NO). These second messengers activate in turn a cascade of downstream proteins via specific oxidations leading to a metabolic response of the cell. This metabolic response can determine proliferation, survival or death of the cell depending on which downstream pathways (homeostatic, pathological, or protective) have been activated. The cells have several sources of H2O2 and cellular systems strictly control its concentration in different subcellular compartments. This review summarizes research on the role played by H2O2 in signaling pathways of eukaryotic cells and how this signaling leads to homeostatic or pathological responses. View Full-Text
Keywords: hydrogen peroxide; redox regulation; oxidative stress hydrogen peroxide; redox regulation; oxidative stress

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Di Marzo, N.; Chisci, E.; Giovannoni, R. The Role of Hydrogen Peroxide in Redox-Dependent Signaling: Homeostatic and Pathological Responses in Mammalian Cells. Cells 2018, 7, 156.

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