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Cells 2018, 7(10), 155; https://doi.org/10.3390/cells7100155

Allogeneic CAR-T Cells: More than Ease of Access?

1
Department of Haematological Medicine, King’s College London, London SE5 9NU, UK
2
Department of Haematology, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UK
3
Department of Clinical and Experimental Medicine, Brighton and Sussex Medical School, University of Sussex, Falmer BN1 9PX, UK
*
Authors to whom correspondence should be addressed.
Received: 10 September 2018 / Revised: 27 September 2018 / Accepted: 27 September 2018 / Published: 1 October 2018
(This article belongs to the Special Issue Emerging Cellular Therapies: T Cells and Beyond)
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Abstract

Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably B-acute lymphoblastic leukaemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL). However, there are limitations, including inability to manufacture CAR-T cells from the patient’s own T cells, disease progression and death prior to return of engineered cells. T cell dysfunction is known to occur in cancer patients, and several groups have recently described differences in CAR-T cells generated from chronic lymphocytic leukaemia (CLL) patients compared with those from a healthy donor. This is thought to contribute to the low response rate in this disease group. Healthy donor, gene-edited CAR-T cells which do not require human leucocyte antigen (HLA) matching have the potential to provide an ‘off the shelf’ product, overcoming the manufacturing difficulties of producing CAR-T cells for each individual patient. They may also provide a more functional, potent product for malignancies such as CLL, where T cell dysfunction is common and frequently cannot be fully reversed during the manufacturing process. Here we review the potential benefits and obstacles for healthy donor, allogeneic CAR-T cells. View Full-Text
Keywords: CAR-T cells; cancer immunotherapy; gene editing CAR-T cells; cancer immunotherapy; gene editing
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Graham, C.; Jozwik, A.; Pepper, A.; Benjamin, R. Allogeneic CAR-T Cells: More than Ease of Access? Cells 2018, 7, 155.

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