Next Article in Journal
Tumor–Stroma Cross-Talk in Human Pancreatic Ductal Adenocarcinoma: A Focus on the Effect of the Extracellular Matrix on Tumor Cell Phenotype and Invasive Potential
Next Article in Special Issue
Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
Previous Article in Journal
The Role of Hydrogen Peroxide in Redox-Dependent Signaling: Homeostatic and Pathological Responses in Mammalian Cells
Previous Article in Special Issue
Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
 
 
Review

Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine (IGMM) University of Edinburgh; Edinburgh EH42XU, Scotland, UK
*
Author to whom correspondence should be addressed.
Cells 2018, 7(10), 157; https://doi.org/10.3390/cells7100157
Received: 4 September 2018 / Revised: 28 September 2018 / Accepted: 3 October 2018 / Published: 5 October 2018
(This article belongs to the Special Issue NF-κB in Cancer)
Nucleoli are emerging as key sensors of cellular stress and regulators of the downstream consequences on proliferation, metabolism, senescence, and apoptosis. NF-κB signalling is activated in response to a similar plethora of stresses, which leads to modulation of cell growth and death programs. While nucleolar and NF-κB pathways are distinct, it is increasingly apparent that they converge at multiple levels. Exposure of cells to certain insults causes a specific type of nucleolar stress that is characterised by degradation of the PolI complex component, TIF-IA, and increased nucleolar size. Recent studies have shown that this atypical nucleolar stress lies upstream of cytosolic IκB degradation and NF-κB nuclear translocation. Under these stress conditions, the RelA component of NF-κB accumulates within functionally altered nucleoli to trigger a nucleophosmin dependent, apoptotic pathway. In this review, we will discuss these points of crosstalk and their relevance to anti-tumour mechanism of aspirin and small molecule CDK4 inhibitors. We will also briefly the discuss how crosstalk between nucleoli and NF-κB signalling may be more broadly relevant to the regulation of cellular homeostasis and how it may be exploited for therapeutic purpose. View Full-Text
Keywords: Nucleolus; TIF-IA(RRN3); I-kappaB; stress; aspirin; CDK4; RelA; p65; cancer; neurodegenerative disorders; NF-κB; non-steroidal anti-inflammatory drugs (NSAIDs) Nucleolus; TIF-IA(RRN3); I-kappaB; stress; aspirin; CDK4; RelA; p65; cancer; neurodegenerative disorders; NF-κB; non-steroidal anti-inflammatory drugs (NSAIDs)
Show Figures

Graphical abstract

MDPI and ACS Style

Chen, J.; Stark, L.A. Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis. Cells 2018, 7, 157. https://doi.org/10.3390/cells7100157

AMA Style

Chen J, Stark LA. Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis. Cells. 2018; 7(10):157. https://doi.org/10.3390/cells7100157

Chicago/Turabian Style

Chen, Jingyu, and Lesley A. Stark. 2018. "Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis" Cells 7, no. 10: 157. https://doi.org/10.3390/cells7100157

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop