Next Article in Journal
Allogeneic CAR-T Cells: More than Ease of Access?
Next Article in Special Issue
AAA Proteases: Guardians of Mitochondrial Function and Homeostasis
Previous Article in Journal
Estrogen Modulates Glycerol Permeability in Sertoli Cells through Downregulation of Aquaporin-9
Previous Article in Special Issue
Mitochondrial Quality Control in COPD and IPF
Open AccessReview

The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis

1
Instituto de Investigaciones Biomédicas, Universidad Autónoma de Chile, Santiago 8910060, Chile
2
School of Engineering and Technology, University of Hertfordshire, Hatfield AL 10 9AB, UK
*
Author to whom correspondence should be addressed.
Cells 2018, 7(10), 154; https://doi.org/10.3390/cells7100154
Received: 23 July 2018 / Revised: 14 September 2018 / Accepted: 25 September 2018 / Published: 29 September 2018
(This article belongs to the Special Issue Mitochondrial Biology in Health and Disease)
PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes. In damaged mitochondria, PINK1’s importing into the inner mitochondrial membrane is prevented, PARKIN presents a partial mitochondrial localization at the outer mitochondrial membrane and DJ-1 relocates to mitochondria when oxidative stress increases. Depletion of these proteins result in abnormal mitochondrial morphology. PINK1, PARKIN, and DJ-1 participate in mitochondrial remodeling and actively regulate mitochondrial quality control. In this review, we highlight that PARKIN, PINK1, and DJ-1 should be regarded as having an important role in Cancer Biology. The STRING database and Gene Ontology (GO) enrichment analysis were performed to consolidate knowledge of well-known protein interactions for PINK1, PARKIN, and DJ-1 and envisage new ones. The enrichment analysis of KEGG pathways showed that the PINK1/PARKIN/DJ-1 network resulted in Parkinson disease as the main feature, while the protein DJ-1 showed enrichment in prostate cancer and p53 signaling pathway. Some predicted transcription factors regulating PINK1, PARK2 (PARKIN) and PARK7 (DJ-1) gene expression are related to cell cycle control. We can therefore suggest that the interplay among PINK1/PARKIN/DJ-1 network during mitochondrial quality control in cancer biology may occur at the transcriptional level. Further analysis, like a systems biology approach, will be helpful in the understanding of PINK1/PARKIN/DJ-1 network. View Full-Text
Keywords: mitochondrial quality control; oxidative stress; PARKIN; PINK1; DJ-1; cancer biology; protein-protein interactions mitochondrial quality control; oxidative stress; PARKIN; PINK1; DJ-1; cancer biology; protein-protein interactions
Show Figures

Graphical abstract

MDPI and ACS Style

Salazar, C.; Ruiz-Hincapie, P.; Ruiz, L.M. The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis. Cells 2018, 7, 154.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop