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The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis

1
Instituto de Investigaciones Biomédicas, Universidad Autónoma de Chile, Santiago 8910060, Chile
2
School of Engineering and Technology, University of Hertfordshire, Hatfield AL 10 9AB, UK
*
Author to whom correspondence should be addressed.
Cells 2018, 7(10), 154; https://doi.org/10.3390/cells7100154
Received: 23 July 2018 / Revised: 14 September 2018 / Accepted: 25 September 2018 / Published: 29 September 2018
(This article belongs to the Special Issue Mitochondrial Biology in Health and Disease)
PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes. In damaged mitochondria, PINK1’s importing into the inner mitochondrial membrane is prevented, PARKIN presents a partial mitochondrial localization at the outer mitochondrial membrane and DJ-1 relocates to mitochondria when oxidative stress increases. Depletion of these proteins result in abnormal mitochondrial morphology. PINK1, PARKIN, and DJ-1 participate in mitochondrial remodeling and actively regulate mitochondrial quality control. In this review, we highlight that PARKIN, PINK1, and DJ-1 should be regarded as having an important role in Cancer Biology. The STRING database and Gene Ontology (GO) enrichment analysis were performed to consolidate knowledge of well-known protein interactions for PINK1, PARKIN, and DJ-1 and envisage new ones. The enrichment analysis of KEGG pathways showed that the PINK1/PARKIN/DJ-1 network resulted in Parkinson disease as the main feature, while the protein DJ-1 showed enrichment in prostate cancer and p53 signaling pathway. Some predicted transcription factors regulating PINK1, PARK2 (PARKIN) and PARK7 (DJ-1) gene expression are related to cell cycle control. We can therefore suggest that the interplay among PINK1/PARKIN/DJ-1 network during mitochondrial quality control in cancer biology may occur at the transcriptional level. Further analysis, like a systems biology approach, will be helpful in the understanding of PINK1/PARKIN/DJ-1 network. View Full-Text
Keywords: mitochondrial quality control; oxidative stress; PARKIN; PINK1; DJ-1; cancer biology; protein-protein interactions mitochondrial quality control; oxidative stress; PARKIN; PINK1; DJ-1; cancer biology; protein-protein interactions
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MDPI and ACS Style

Salazar, C.; Ruiz-Hincapie, P.; Ruiz, L.M. The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis. Cells 2018, 7, 154. https://doi.org/10.3390/cells7100154

AMA Style

Salazar C, Ruiz-Hincapie P, Ruiz LM. The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis. Cells. 2018; 7(10):154. https://doi.org/10.3390/cells7100154

Chicago/Turabian Style

Salazar, Celia, Paula Ruiz-Hincapie, and Lina M. Ruiz 2018. "The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis" Cells 7, no. 10: 154. https://doi.org/10.3390/cells7100154

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