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Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

College of Pharmacy and Medical Research Center, Chungbuk National University, 194-31, Osongsaengmyeong 1-ro, Osong-eup, Cheongwon-gun, Chungbuk 28160, Korea
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Academic Editor: Ruaidhri Carmody
Cells 2016, 5(2), 15; https://doi.org/10.3390/cells5020015
Received: 22 February 2016 / Revised: 22 March 2016 / Accepted: 24 March 2016 / Published: 29 March 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, inflammatory bowel diseases, multiple sclerosis and malignant tumors. Thus, inhibiting NF-κB signaling has potential therapeutic applications in cancer and inflammatory diseases. View Full-Text
Keywords: NF-κB; canonical pathway; non-canonical pathway; cancer; inflammatory disease; therapeutic approaches NF-κB; canonical pathway; non-canonical pathway; cancer; inflammatory disease; therapeutic approaches
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Park, M.H.; Hong, J.T. Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches. Cells 2016, 5, 15.

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