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Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, Scotland, UK
Authors to whom correspondence should be addressed.
Academic Editor: Alexander E. Kalyuzhny
Cells 2016, 5(2), 14;
Received: 8 February 2016 / Revised: 17 March 2016 / Accepted: 17 March 2016 / Published: 24 March 2016
(This article belongs to the Special Issue Cellular and Molecular Biology of NF-κB)
Bcl-3 is a member of the IκB family of proteins and an important regulator of Nuclear Factor (NF)-κB activity. The ability of Bcl-3 to bind and regulate specific NF-κB dimers has been studied in great depth, but its physiological roles in vivo are still not fully understood. It is, however, becoming clear that Bcl-3 is essential for the proper development, survival and activity of adaptive immune cells. Bcl-3 dysregulation can be observed in a number of autoimmune pathologies, and Bcl3-deficient animals are more susceptible to bacterial and parasitic infection. This review will describe our current understanding of the roles played by Bcl-3 in the development and regulation of the adaptive immune response, including lymphoid organogenesis, immune tolerance, lymphocyte function and dendritic cell biology. View Full-Text
Keywords: NF-κB; Bcl-3; adaptive immunity; inflammation NF-κB; Bcl-3; adaptive immunity; inflammation
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Herrington, F.D.; Nibbs, R.J.B. Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3. Cells 2016, 5, 14.

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