Next Article in Journal
What Is the Significance of Lysosomal-Mediated Resistance to Imatinib?
Previous Article in Journal
Tuning between Nuclear Organization and Functionality in Health and Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 12
Issue 5
10.3390/cells12050707
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Hypotheses on Atherogenesis Triggering: Does the Infectious Nature of Atherosclerosis Development Have a Substruction?

by
Konstantin A. Lusta
1,
Anastasia V. Poznyak
1,*,
Vasily N. Sukhorukov
2,3,
Ilya I. Eremin
3,
Irina I. Nadelyaeva
3 and
Alexander N. Orekhov
1,2,*
1
Institute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia
2
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiiskaya Street, 125315 Moscow, Russia
3
Petrovsky National Research Centre of Surgery, 2, Abrikosovsky Lane, 119991 Moscow, Russia
*
Authors to whom correspondence should be addressed.
Cells 2023, 12(5), 707; https://doi.org/10.3390/cells12050707
Submission received: 19 December 2022 / Revised: 3 February 2023 / Accepted: 21 February 2023 / Published: 23 February 2023
(This article belongs to the Special Issue Involvement of Inflammation in Pathogenesis of Arterial and Venous Thromboembolic Disease)
Versions Notes

Abstract

Since the end of the 20th century, it has been clear that atherosclerosis is an inflammatory disease. However, the main triggering mechanism of the inflammatory process in the vascular walls is still unclear. To date, many different hypotheses have been put forward to explain the causes of atherogenesis, and all of them are supported by strong evidence. Among the main causes of atherosclerosis, which underlies these hypotheses, the following can be mentioned: lipoprotein modification, oxidative transformation, shear stress, endothelial dysfunction, free radicals’ action, homocysteinemia, diabetes mellitus, and decreased nitric oxide level. One of the latest hypotheses concerns the infectious nature of atherogenesis. The currently available data indicate that pathogen-associated molecular patterns from bacteria or viruses may be an etiological factor in atherosclerosis. This paper is devoted to the analysis of existing hypotheses for atherogenesis triggering, and special attention is paid to the contribution of bacterial and viral infections to the pathogenesis of atherosclerosis and cardiovascular disease.
Keywords: atherosclerosis; cardiovascular disease; inflammation; infections; lipoprotein modification; endothelial dysfunction; pathogen-associated molecular patterns; cytokines atherosclerosis; cardiovascular disease; inflammation; infections; lipoprotein modification; endothelial dysfunction; pathogen-associated molecular patterns; cytokines

Share and Cite

MDPI and ACS Style

Lusta, K.A.; Poznyak, A.V.; Sukhorukov, V.N.; Eremin, I.I.; Nadelyaeva, I.I.; Orekhov, A.N. Hypotheses on Atherogenesis Triggering: Does the Infectious Nature of Atherosclerosis Development Have a Substruction? Cells 2023, 12, 707. https://doi.org/10.3390/cells12050707

AMA Style

Lusta KA, Poznyak AV, Sukhorukov VN, Eremin II, Nadelyaeva II, Orekhov AN. Hypotheses on Atherogenesis Triggering: Does the Infectious Nature of Atherosclerosis Development Have a Substruction? Cells. 2023; 12(5):707. https://doi.org/10.3390/cells12050707

Chicago/Turabian Style

Lusta, Konstantin A., Anastasia V. Poznyak, Vasily N. Sukhorukov, Ilya I. Eremin, Irina I. Nadelyaeva, and Alexander N. Orekhov. 2023. "Hypotheses on Atherogenesis Triggering: Does the Infectious Nature of Atherosclerosis Development Have a Substruction?" Cells 12, no. 5: 707. https://doi.org/10.3390/cells12050707

APA Style

Lusta, K. A., Poznyak, A. V., Sukhorukov, V. N., Eremin, I. I., Nadelyaeva, I. I., & Orekhov, A. N. (2023). Hypotheses on Atherogenesis Triggering: Does the Infectious Nature of Atherosclerosis Development Have a Substruction? Cells, 12(5), 707. https://doi.org/10.3390/cells12050707

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop