Innate Immunity and CKD: Is There a Significant Association?
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsThe authors present a review tittle "Innate immunity and CKD – is there a significant association? ". However, this association is poorly described and basic concepts are present throughout the manuscript.
Much research is lacking and the attempt to associate what happens when the immune response receptors are activated and how these contribute to the development and evolution of the CKD is lost. That is the main weakness of the manuscript.
No figures are shown. I suggest that the authors present illustrative figures that allow the readers to immerse in the highlighted association. For instance, NLRP3 pathway-induced CKD. But,... how does this happen?
Comments on the Quality of English Language
NO COMENTS
Author Response
attached is the two figures advised to be added for vivid explanation of the pathways and treatments discussed in the manuscript
Author Response File: 
Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsThe relationship between innate immunity and CKD is a complex and multifaceted topic that has been a subject of research and debate. Innate immunity, can become dysregulated in CKD, leading to inflammation and tissue damage. Chronic inflammation has been linked to the progression of kidney disease and is associated with worse outcomes in CKD patients.
Additionally, various immune cells, cytokines, and molecules involved in innate immunity have been implicated in the pathogenesis of CKD. Toll-like receptors (TLRs) and inflammasomes, for example, have been studied for their role in initiating and perpetuating inflammation in CKD.
In the present manuscript the authors brilliantly addresses the intricate relationship between innate immunity and CKD, which is essential for advancing our understanding of CKD and its underlying mechanisms.
This manuscript not only adds to the existing body of knowledge but also serves as an excellent resource for researchers and healthcare professionals interested in this field.
Overall, I highly recommend the acceptance and publication of this manuscript in the present form.
Author Response
Thank you for your thorough comments.
I am adding the second figure here as there is no option for two files to be uploaded in the answer to the first reviewer.
Author Response File: Author Response.pdf
Reviewer 3 Report
Comments and Suggestions for AuthorsThis paper gives extensive description of studies relating the immune system and chronic kidney disease. All in all, the review succeeds, but there are some sections that are poorly referenced, and a number of typographical errors that need to be fixed.
1. Are there no older reviews to reference at the beginning of your paper? Such would be helpful for a reader seeking to explore this field.
2. A whole string of paragraphs starting at section 1.1 and extending into 1.2 have no references at all. Please give citations for these statements.
3. The mention of Henke et al. in ll. 233-237 has no reference numbered there. When I looked up Henke in the document, I note that it appears twice in the references.
4. Line 388: ‘these’ is misspelled.
5. Line 391: ‘point’ should be pointed’
Comments on the Quality of English Language
Fine.
Author Response
We have revised the references, added in the section were there were lacking, and addressed duplicates, and "Henke et al" is the older review. The "these" and "point" were corrected.
Round 2
Reviewer 1 Report
Comments and Suggestions for AuthorsThe authors have addressed my concerns. The manuscript might be accepted in the current form.
Comments on the Quality of English LanguageEnglish is fine.
