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Review

The Underestimated Role of Platelets in Severe Infection a Narrative Review

by
Alberto Fogagnolo
1,*,
Gianluca Calogero Campo
2,3,
Matilde Mari
1,
Graziella Pompei
2,3,
Rita Pavasini
2,3,
Carlo Alberto Volta
1 and
Savino Spadaro
1
1
Intensive Care Unit, Department of Translational Medicine and for Romagna, Azienda Ospedaliera Universitaria di Ferrara, University of Ferrara, 44121 Ferrara, Italy
2
Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, 44124 Cona, Italy
3
Maria Cecilia Hospital, GVM Care and Research, 48032 Cotignola, Italy
*
Author to whom correspondence should be addressed.
Cells 2022, 11(3), 424; https://doi.org/10.3390/cells11030424
Submission received: 6 December 2021 / Revised: 16 January 2022 / Accepted: 23 January 2022 / Published: 26 January 2022
(This article belongs to the Special Issue Role of Platelets in Inflammatory Diseases)
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Abstract

Beyond their role in hemostasis, platelets have emerged as key contributors in the immune response; accordingly, the occurrence of thrombocytopenia during sepsis/septic shock is a well-known risk factor of mortality and a marker of disease severity. Recently, some studies elucidated that the response of platelets to infections goes beyond a simple fall in platelets count; indeed, sepsis-induced thrombocytopenia can be associated with—or even anticipated by—several changes, including an altered morphological pattern, receptor expression and aggregation. Of note, alterations in platelet function and morphology can occur even with a normal platelet count and can modify, depending on the nature of the pathogen, the pattern of host response and the severity of the infection. The purpose of this review is to give an overview on the pathophysiological interaction between platelets and pathogens, as well as the clinical consequences of platelet dysregulation. Furthermore, we try to clarify how understanding the nature of platelet dysregulation may help to optimize the therapeutic approach.
Keywords: platelet; platelet activation; infection; critical care platelet; platelet activation; infection; critical care
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MDPI and ACS Style

Fogagnolo, A.; Campo, G.C.; Mari, M.; Pompei, G.; Pavasini, R.; Volta, C.A.; Spadaro, S. The Underestimated Role of Platelets in Severe Infection a Narrative Review. Cells 2022, 11, 424. https://doi.org/10.3390/cells11030424

AMA Style

Fogagnolo A, Campo GC, Mari M, Pompei G, Pavasini R, Volta CA, Spadaro S. The Underestimated Role of Platelets in Severe Infection a Narrative Review. Cells. 2022; 11(3):424. https://doi.org/10.3390/cells11030424

Chicago/Turabian Style

Fogagnolo, Alberto, Gianluca Calogero Campo, Matilde Mari, Graziella Pompei, Rita Pavasini, Carlo Alberto Volta, and Savino Spadaro. 2022. "The Underestimated Role of Platelets in Severe Infection a Narrative Review" Cells 11, no. 3: 424. https://doi.org/10.3390/cells11030424

APA Style

Fogagnolo, A., Campo, G. C., Mari, M., Pompei, G., Pavasini, R., Volta, C. A., & Spadaro, S. (2022). The Underestimated Role of Platelets in Severe Infection a Narrative Review. Cells, 11(3), 424. https://doi.org/10.3390/cells11030424

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