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Cells
Volume 11
Issue 24
10.3390/cells11244091
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Article

Icariin Treatment Rescues Diabetes Induced Bone Loss via Scavenging ROS and Activating Primary Cilia/Gli2/Osteocalcin Signaling Pathway

by
Jie Liu
1,†,
Qingfeng Cheng
2,†,
Xiangmei Wu
3,†,
Huifang Zhu
1,
Xiaoyan Deng
1,
Maorong Wang
4,
Shengyong Yang
1,
Jie Xu
1,
Qian Chen
1,
Mengxue Li
1,
Xianjun Liu
1 and
Changdong Wang
1,*
1
Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China
2
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 401331, China
3
Department of Physiology, Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China
4
Department of Endocrinology, Affiliated Hospital of Hubei University for Nationalities, Enshi 445000, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2022, 11(24), 4091; https://doi.org/10.3390/cells11244091
Submission received: 24 October 2022 / Revised: 10 December 2022 / Accepted: 14 December 2022 / Published: 16 December 2022
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Abstract

Diabetes-associated bone complications lead to fragile bone mechanical strength and osteoporosis, aggravating the disease burden of patients. Advanced evidence shows that chronic hyperglycemia and metabolic intermediates, such as inflammatory factor, reactive oxygen species (ROS), and advanced glycation end products (AGEs), are regarded as dominant hazardous factors of bone complications, whereas the pathophysiological mechanisms are complex and controversial. By establishing a diabetic Sprague-Dawley (SD) rat model and diabetic bone loss cell model in vitro, we confirmed that diabetes impaired primary cilia and led to bone loss, while adding Icariin (ICA) could relieve the inhibitions. Mechanistically, ICA could scavenge ROS to maintain the mitochondrial and primary cilia homeostasis of osteoblasts. Intact primary cilia acted as anchoring and modifying sites of Gli2, thereby activating the primary cilia/Gli2/osteocalcin signaling pathway to promote osteoblast differentiation. All results suggest that ICA has potential as a therapeutic drug targeting bone loss induced by diabetes.
Keywords: diabetes; bone loss; primary cilia; Icariin; ROS diabetes; bone loss; primary cilia; Icariin; ROS

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MDPI and ACS Style

Liu, J.; Cheng, Q.; Wu, X.; Zhu, H.; Deng, X.; Wang, M.; Yang, S.; Xu, J.; Chen, Q.; Li, M.; et al. Icariin Treatment Rescues Diabetes Induced Bone Loss via Scavenging ROS and Activating Primary Cilia/Gli2/Osteocalcin Signaling Pathway. Cells 2022, 11, 4091. https://doi.org/10.3390/cells11244091

AMA Style

Liu J, Cheng Q, Wu X, Zhu H, Deng X, Wang M, Yang S, Xu J, Chen Q, Li M, et al. Icariin Treatment Rescues Diabetes Induced Bone Loss via Scavenging ROS and Activating Primary Cilia/Gli2/Osteocalcin Signaling Pathway. Cells. 2022; 11(24):4091. https://doi.org/10.3390/cells11244091

Chicago/Turabian Style

Liu, Jie, Qingfeng Cheng, Xiangmei Wu, Huifang Zhu, Xiaoyan Deng, Maorong Wang, Shengyong Yang, Jie Xu, Qian Chen, Mengxue Li, and et al. 2022. "Icariin Treatment Rescues Diabetes Induced Bone Loss via Scavenging ROS and Activating Primary Cilia/Gli2/Osteocalcin Signaling Pathway" Cells 11, no. 24: 4091. https://doi.org/10.3390/cells11244091

APA Style

Liu, J., Cheng, Q., Wu, X., Zhu, H., Deng, X., Wang, M., Yang, S., Xu, J., Chen, Q., Li, M., Liu, X., & Wang, C. (2022). Icariin Treatment Rescues Diabetes Induced Bone Loss via Scavenging ROS and Activating Primary Cilia/Gli2/Osteocalcin Signaling Pathway. Cells, 11(24), 4091. https://doi.org/10.3390/cells11244091

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