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Cells
Volume 11
Issue 22
10.3390/cells11223653
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Review

Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury

by
Linxiang Zhou
1,†,
Shangting Han
2,†,
Jiayu Guo
2,
Tao Qiu
2,
Jiangqiao Zhou
2,* and
Lei Shen
1,*
1
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China
2
Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2022, 11(22), 3653; https://doi.org/10.3390/cells11223653
Submission received: 18 October 2022 / Revised: 12 November 2022 / Accepted: 16 November 2022 / Published: 17 November 2022
(This article belongs to the Special Issue Molecular Mechanisms Underlying Organ Damage in Ischemia and Reperfusion Injury)
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Abstract

Ischemia–reperfusion (I/R) is a common pathological phenomenon that occurs in numerous organs and diseases. It generally results from secondary damage caused by the recovery of blood flow and reoxygenation, followed by ischemia of organ tissues, which is often accompanied by severe cellular damage and death. Currently, effective treatments for I/R injury (IRI) are limited. Ferroptosis, a new type of regulated cell death (RCD), is characterized by iron overload and iron-dependent lipid peroxidation. Mounting evidence has indicated a close relationship between ferroptosis and IRI. Ferroptosis plays a significantly detrimental role in the progression of IRI, and targeting ferroptosis may be a promising approach for treatment of IRI. Considering the substantial progress made in the study of ferroptosis in IRI, in this review, we summarize the pathological mechanisms and therapeutic targets of ferroptosis in IRI.
Keywords: ischemia–reperfusion injury; treatment; mechanism; ferroptosis; lipid peroxidation ischemia–reperfusion injury; treatment; mechanism; ferroptosis; lipid peroxidation

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MDPI and ACS Style

Zhou, L.; Han, S.; Guo, J.; Qiu, T.; Zhou, J.; Shen, L. Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury. Cells 2022, 11, 3653. https://doi.org/10.3390/cells11223653

AMA Style

Zhou L, Han S, Guo J, Qiu T, Zhou J, Shen L. Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury. Cells. 2022; 11(22):3653. https://doi.org/10.3390/cells11223653

Chicago/Turabian Style

Zhou, Linxiang, Shangting Han, Jiayu Guo, Tao Qiu, Jiangqiao Zhou, and Lei Shen. 2022. "Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury" Cells 11, no. 22: 3653. https://doi.org/10.3390/cells11223653

APA Style

Zhou, L., Han, S., Guo, J., Qiu, T., Zhou, J., & Shen, L. (2022). Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury. Cells, 11(22), 3653. https://doi.org/10.3390/cells11223653

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