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Review

Molecular Mechanism of Ferroptosis in Orthopedic Diseases

by
Lu Gao
1,†,
Weizhong Hua
1,†,
Lixiang Tian
2,
Xuchang Zhou
1,
Dongxue Wang
1,
Yajing Yang
3 and
Guoxin Ni
1,*
1
School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China
2
School of Physical Education, Shanghai University, Shanghai 200444, China
3
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2022, 11(19), 2979; https://doi.org/10.3390/cells11192979
Submission received: 24 August 2022 / Revised: 19 September 2022 / Accepted: 20 September 2022 / Published: 24 September 2022
(This article belongs to the Special Issue Novel Mechanisms and Therapeutic Opportunities of Ferroptosis)
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Abstract

Ferroptosis is a new iron-dependent programmed cell death process that is directly mediated by the accumulation of lipid peroxides and reactive oxygen species. Numerous studies have shown that ferroptosis is important in regulating the occurrence and development of bone-related diseases, but the underlying mechanisms are not completely clear. Herein, we review the progress of the mechanism of ferroptosis in bone marrow injury, osteoporosis, osteoarthritis, and osteosarcoma and attempt to deeply understand the regulatory targets of ferroptosis, which will open up a new way for the prevention and treatment of orthopedic diseases.
Keywords: ferroptosis; regulation of ferroptosis; bone marrow injury; osteoporosis; osteoarthritis; osteosarcoma; orthopedic disease ferroptosis; regulation of ferroptosis; bone marrow injury; osteoporosis; osteoarthritis; osteosarcoma; orthopedic disease

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MDPI and ACS Style

Gao, L.; Hua, W.; Tian, L.; Zhou, X.; Wang, D.; Yang, Y.; Ni, G. Molecular Mechanism of Ferroptosis in Orthopedic Diseases. Cells 2022, 11, 2979. https://doi.org/10.3390/cells11192979

AMA Style

Gao L, Hua W, Tian L, Zhou X, Wang D, Yang Y, Ni G. Molecular Mechanism of Ferroptosis in Orthopedic Diseases. Cells. 2022; 11(19):2979. https://doi.org/10.3390/cells11192979

Chicago/Turabian Style

Gao, Lu, Weizhong Hua, Lixiang Tian, Xuchang Zhou, Dongxue Wang, Yajing Yang, and Guoxin Ni. 2022. "Molecular Mechanism of Ferroptosis in Orthopedic Diseases" Cells 11, no. 19: 2979. https://doi.org/10.3390/cells11192979

APA Style

Gao, L., Hua, W., Tian, L., Zhou, X., Wang, D., Yang, Y., & Ni, G. (2022). Molecular Mechanism of Ferroptosis in Orthopedic Diseases. Cells, 11(19), 2979. https://doi.org/10.3390/cells11192979

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