Next Article in Journal
Drepmel—A Multi-Omics Melanoma Drug Repurposing Resource for Prioritizing Drug Combinations and Understanding Tumor Microenvironment
Next Article in Special Issue
From Differential DNA Methylation in COPD to Mitochondria: Regulation of AHRR Expression Affects Airway Epithelial Response to Cigarette Smoke
Previous Article in Journal
Cell Tracking by Magnetic Particle Imaging: Methodology for Labeling THP-1 Monocytes with Magnetic Nanoparticles for Cellular Imaging
Previous Article in Special Issue
Cigarette Smoke Extract Disturbs Mitochondria-Regulated Airway Epithelial Cell Responses to Pneumococci
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 11
Issue 18
10.3390/cells11182893
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies

by
Lei Wang
1,
Lieke E. J. van Iersel
2,
Charlotte E. Pelgrim
1,
Jingyi Lu
1,
Ingrid van Ark
1,
Thea Leusink-Muis
1,
Harry R. Gosker
2,
Ramon C. J. Langen
2,
Annemie M. W. J. Schols
2,
Josep M. Argilés
3,
Ardy van Helvoort
2,4,
Aletta D. Kraneveld
1,
Johan Garssen
1,4,
Paul A. J. Henricks
1,
Gert Folkerts
1 and
Saskia Braber
1,*
1
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands
2
Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, 6200 MD Maastricht, The Netherlands
3
Biochemistry and Molecular Biology of Cancer, Faculty of Biology, University of Barcelona, 08007 Barcelona, Spain
4
Danone Nutricia Research, 3584 CT Utrecht, The Netherlands
*
Author to whom correspondence should be addressed.
Cells 2022, 11(18), 2893; https://doi.org/10.3390/cells11182893
Submission received: 1 August 2022 / Revised: 31 August 2022 / Accepted: 6 September 2022 / Published: 16 September 2022
(This article belongs to the Special Issue Metabolic Alterations and Cellular Stress Responses in Chronic Obstructive Pulmonary Disease)
Browse Figures
Versions Notes

Abstract

Chronic obstructive pulmonary disease (COPD), often caused by smoking, is a chronic lung disease with systemic manifestations including metabolic comorbidities. This study investigates adaptive and pathological alterations in adipose and skeletal muscle tissue following cigarette smoke exposure using in vivo and in vitro models. Mice were exposed to cigarette smoke or air for 72 days and the pre-adipose cell line 3T3-L1 was utilized as an in vitro model. Cigarette smoke exposure decreased body weight, and the proportional loss in fat mass was more pronounced than the lean mass loss. Cigarette smoke exposure reduced adipocyte size and increased adipocyte numbers. Adipose macrophage numbers and associated cytokine levels, including interleukin-1β, interleukine-6 and tumor necrosis factor-α were elevated in smoke-exposed mice. Muscle strength and protein synthesis signaling were decreased after smoke exposure; however, muscle mass was not changed. In vitro studies demonstrated that lipolysis and fatty acid oxidation were upregulated in cigarette smoke-exposed pre-adipocytes. In conclusion, cigarette smoke exposure induces a loss of whole-body fat mass and adipose atrophy, which is likely due to enhanced lipolysis.
Keywords: COPD; cigarette smoke; cachexia; adipose tissue; lipolysis; skeletal muscle COPD; cigarette smoke; cachexia; adipose tissue; lipolysis; skeletal muscle

Share and Cite

MDPI and ACS Style

Wang, L.; van Iersel, L.E.J.; Pelgrim, C.E.; Lu, J.; van Ark, I.; Leusink-Muis, T.; Gosker, H.R.; Langen, R.C.J.; Schols, A.M.W.J.; Argilés, J.M.; et al. Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies. Cells 2022, 11, 2893. https://doi.org/10.3390/cells11182893

AMA Style

Wang L, van Iersel LEJ, Pelgrim CE, Lu J, van Ark I, Leusink-Muis T, Gosker HR, Langen RCJ, Schols AMWJ, Argilés JM, et al. Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies. Cells. 2022; 11(18):2893. https://doi.org/10.3390/cells11182893

Chicago/Turabian Style

Wang, Lei, Lieke E. J. van Iersel, Charlotte E. Pelgrim, Jingyi Lu, Ingrid van Ark, Thea Leusink-Muis, Harry R. Gosker, Ramon C. J. Langen, Annemie M. W. J. Schols, Josep M. Argilés, and et al. 2022. "Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies" Cells 11, no. 18: 2893. https://doi.org/10.3390/cells11182893

APA Style

Wang, L., van Iersel, L. E. J., Pelgrim, C. E., Lu, J., van Ark, I., Leusink-Muis, T., Gosker, H. R., Langen, R. C. J., Schols, A. M. W. J., Argilés, J. M., van Helvoort, A., Kraneveld, A. D., Garssen, J., Henricks, P. A. J., Folkerts, G., & Braber, S. (2022). Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies. Cells, 11(18), 2893. https://doi.org/10.3390/cells11182893

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop