Next Article in Journal
Ciliary Dyneins and Dynein Related Ciliopathies
Next Article in Special Issue
Presynaptic AMPA Receptors in Health and Disease
Previous Article in Journal
Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis
Previous Article in Special Issue
Reduced mGluR5 Activity Modulates Mitochondrial Function
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 10
Issue 8
10.3390/cells10081884
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease

by
Don A. Davies
1,*,†,
Aida Adlimoghaddam
1,† and
Benedict C. Albensi
1,2,*
1
Division of Neurodegenerative Disorders, St. Boniface Hospital Research, Winnipeg, MB R2H 2A6, Canada
2
Department of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, MB R3E 0T6, Canada
*
Authors to whom correspondence should be addressed.
†
These authors contributed to this work equally.
Cells 2021, 10(8), 1884; https://doi.org/10.3390/cells10081884
Submission received: 26 June 2021 / Revised: 20 July 2021 / Accepted: 23 July 2021 / Published: 25 July 2021
(This article belongs to the Special Issue Synaptic Dysfunction in Health and Disease)
Browse Figures
Versions Notes

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that reduces oxidative stress. When reactive oxygen species (ROS) or reactive nitrogen species (RNS) are detected, Nrf2 translocates from the cytoplasm into the nucleus and binds to the antioxidant response element (ARE), which regulates the expression of antioxidant and anti-inflammatory genes. Nrf2 impairments are observed in the majority of neurodegenerative disorders, including Alzheimer’s disease (AD). The classic hallmarks of AD include β-amyloid (Aβ) plaques, and neurofibrillary tangles (NFTs). Oxidative stress is observed early in AD and is a novel therapeutic target for the treatment of AD. The nuclear translocation of Nrf2 is impaired in AD compared to controls. Increased oxidative stress is associated with impaired memory and synaptic plasticity. The administration of Nrf2 activators reverses memory and synaptic plasticity impairments in rodent models of AD. Therefore, Nrf2 activators are a potential novel therapeutic for neurodegenerative disorders including AD.
Keywords: NF-κB; neurodegeneration; oxidative stress; reactive oxygen species; inflammation NF-κB; neurodegeneration; oxidative stress; reactive oxygen species; inflammation

Share and Cite

MDPI and ACS Style

Davies, D.A.; Adlimoghaddam, A.; Albensi, B.C. Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease. Cells 2021, 10, 1884. https://doi.org/10.3390/cells10081884

AMA Style

Davies DA, Adlimoghaddam A, Albensi BC. Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease. Cells. 2021; 10(8):1884. https://doi.org/10.3390/cells10081884

Chicago/Turabian Style

Davies, Don A., Aida Adlimoghaddam, and Benedict C. Albensi. 2021. "Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease" Cells 10, no. 8: 1884. https://doi.org/10.3390/cells10081884

APA Style

Davies, D. A., Adlimoghaddam, A., & Albensi, B. C. (2021). Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease. Cells, 10(8), 1884. https://doi.org/10.3390/cells10081884

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop