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Review

A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies

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Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07747 Jena, Germany
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Septomics Research Center, Jena University Hospital, 07747 Jena, Germany
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Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany
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Department of Diabetology Endocrinology and Nephrology, University Hospital Tübingen, Eberhard Karls University Tübingen, 72074 Tübingen, Germany
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Department of Therapy of Diabetes, Institute of Diabetes Research and Metabolic Diseases in the Helmholtz Center Munich, Eberhard Karls University Tübingen, 72074 Tübingen, Germany
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Division of Diabetes and Nutritional Sciences, Rayne Institute, King’s College London, London SE5 9RJ, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Yury Ladilov and Muhammad Aslam
Cells 2021, 10(7), 1822; https://doi.org/10.3390/cells10071822
Received: 3 May 2021 / Revised: 1 July 2021 / Accepted: 15 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Advances in AMPK Research: Basic and Translational Aspects)
5′AMP-activated protein kinase (AMPK) is known as metabolic sensor in mammalian cells that becomes activated by an increasing adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio. The heterotrimeric AMPK protein comprises three subunits, each of which has multiple phosphorylation sites, playing an important role in the regulation of essential molecular pathways. By phosphorylation of downstream proteins and modulation of gene transcription AMPK functions as a master switch of energy homeostasis in tissues with high metabolic turnover, such as the liver, skeletal muscle, and adipose tissue. Regulation of AMPK under conditions of chronic caloric oversupply emerged as substantial research target to get deeper insight into the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Evidence supporting the role of AMPK in NAFLD is mainly derived from preclinical cell culture and animal studies. Dysbalanced de novo lipogenesis has been identified as one of the key processes in NAFLD pathogenesis. Thus, the scope of this review is to provide an integrative overview of evidence, in particular from clinical studies and human samples, on the role of AMPK in the regulation of primarily de novo lipogenesis in human NAFLD. View Full-Text
Keywords: lipotoxicity; insulin resistance; free fatty acids; steatohepatitis; type 2 diabetes; skeletal muscle; adipose tissue; diacylglycerol lipotoxicity; insulin resistance; free fatty acids; steatohepatitis; type 2 diabetes; skeletal muscle; adipose tissue; diacylglycerol
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MDPI and ACS Style

von Loeffelholz, C.; Coldewey, S.M.; Birkenfeld, A.L. A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies. Cells 2021, 10, 1822. https://doi.org/10.3390/cells10071822

AMA Style

von Loeffelholz C, Coldewey SM, Birkenfeld AL. A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies. Cells. 2021; 10(7):1822. https://doi.org/10.3390/cells10071822

Chicago/Turabian Style

von Loeffelholz, Christian, Sina M. Coldewey, and Andreas L. Birkenfeld 2021. "A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies" Cells 10, no. 7: 1822. https://doi.org/10.3390/cells10071822

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