Next Article in Journal
A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies
Next Article in Special Issue
Nuclear Dynamics and Chromatin Structure: Implications for Pancreatic Cancer
Previous Article in Journal
Distinctive Prognostic Value and Cellular Functions of Osteopontin Splice Variants in Human Gastric Cancer
Previous Article in Special Issue
Targeting HDACs in Pancreatic Neuroendocrine Tumor Models
Article

Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma

1
Department of Medicine II, University Hospital, LMU Munich, 81377 Munich, Germany
2
Department of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany
3
Department for Visceral, Thoracic and Vascular Surgery, University Hospital, Technical University Dresden, 01307 Dresden, Germany
4
Department of General and Visceral Surgery, Katholisches Klinikum Bochum, 44791 Bochum, Germany
5
Department of General and Visceral Surgery, Asklepios Klinikum Hamburg, 21075 Hamburg, Germany
6
Zentrum für Onkologische Oberbauchchirurgie und Robotik, Krankenhaus Waldfriede, 14163 Berlin, Germany
7
Department of General, Visceral and Transplantation Surgery, Charité, Campus Virchow Klinikum, 13353 Berlin, Germany
8
Department of Surgery, Erlangen University Hospital, 91054 Erlangen, Germany
9
University Hospital, LMU Munich, 81377 Munich, Germany
10
Department of Radiation Oncology, LMU Munich, 81377 Munich, Germany
11
TrinamiX GmbH, 67063 Ludwigshafen am Rhein, Germany
12
Metanomics-Health GmbH, 10589 Berlin, Germany
*
Author to whom correspondence should be addressed.
These authors share senior authorship.
Academic Editors: Albrecht Neesse and Elisabeth Hessmann
Cells 2021, 10(7), 1821; https://doi.org/10.3390/cells10071821
Received: 8 June 2021 / Revised: 14 July 2021 / Accepted: 15 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Genome Dynamics in Pancreatic Cancer Biology and Therapy)
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Developing biomarkers for early detection and chemotherapeutic response prediction is crucial to improve the dismal prognosis of PDAC patients. However, molecular cancer signatures based on transcriptome analysis do not reflect intratumoral heterogeneity. To explore a more accurate stratification of PDAC phenotypes in an easily accessible matrix, plasma metabolome analysis using MxP® Global Profiling and MxP® Lipidomics was performed in 361 PDAC patients. We identified three metabolic PDAC subtypes associated with distinct complex lipid patterns. Subtype 1 was associated with reduced ceramide levels and a strong enrichment of triacylglycerols. Subtype 2 demonstrated increased abundance of ceramides, sphingomyelin and other complex sphingolipids, whereas subtype 3 showed decreased levels of sphingolipid metabolites in plasma. Pathway enrichment analysis revealed that sphingolipid-related pathways differ most among subtypes. Weighted correlation network analysis (WGCNA) implied PDAC subtypes differed in their metabolic programs. Interestingly, a reduced expression among related pathway genes in tumor tissue was associated with the lowest survival rate. However, our metabolic PDAC subtypes did not show any correlation to the described molecular PDAC subtypes. Our findings pave the way for further studies investigating sphingolipids metabolisms in PDAC. View Full-Text
Keywords: pancreatic ductal adenocarcinoma; complex lipids; sphingolipids; metabolic subtypes pancreatic ductal adenocarcinoma; complex lipids; sphingolipids; metabolic subtypes
Show Figures

Figure 1

MDPI and ACS Style

Mahajan, U.M.; Alnatsha, A.; Li, Q.; Oehrle, B.; Weiss, F.-U.; Sendler, M.; Distler, M.; Uhl, W.; Fahlbusch, T.; Goni, E.; Beyer, G.; Chromik, A.; Bahra, M.; Klein, F.; Pilarsky, C.; Grützmann, R.; Lerch, M.M.; Lauber, K.; Christiansen, N.; Kamlage, B.; Regel, I.; Mayerle, J. Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma. Cells 2021, 10, 1821. https://doi.org/10.3390/cells10071821

AMA Style

Mahajan UM, Alnatsha A, Li Q, Oehrle B, Weiss F-U, Sendler M, Distler M, Uhl W, Fahlbusch T, Goni E, Beyer G, Chromik A, Bahra M, Klein F, Pilarsky C, Grützmann R, Lerch MM, Lauber K, Christiansen N, Kamlage B, Regel I, Mayerle J. Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma. Cells. 2021; 10(7):1821. https://doi.org/10.3390/cells10071821

Chicago/Turabian Style

Mahajan, Ujjwal M., Ahmed Alnatsha, Qi Li, Bettina Oehrle, Frank-Ulrich Weiss, Matthias Sendler, Marius Distler, Waldemar Uhl, Tim Fahlbusch, Elisabetta Goni, Georg Beyer, Ansgar Chromik, Markus Bahra, Fritz Klein, Christian Pilarsky, Robert Grützmann, Markus M. Lerch, Kirsten Lauber, Nicole Christiansen, Beate Kamlage, Ivonne Regel, and Julia Mayerle. 2021. "Plasma Metabolome Profiling Identifies Metabolic Subtypes of Pancreatic Ductal Adenocarcinoma" Cells 10, no. 7: 1821. https://doi.org/10.3390/cells10071821

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop