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Cells
Volume 10
Issue 7
10.3390/cells10071722
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Review

How Influenza Virus Uses Host Cell Pathways during Uncoating

by
Etori Aguiar Moreira
1,
Yohei Yamauchi
2 and
Patrick Matthias
1,3,*
1
Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
2
Faculty of Life Sciences, School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK
3
Faculty of Sciences, University of Basel, 4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Cells 2021, 10(7), 1722; https://doi.org/10.3390/cells10071722
Submission received: 7 May 2021 / Revised: 25 June 2021 / Accepted: 2 July 2021 / Published: 8 July 2021
(This article belongs to the Special Issue Virus — Host Cell Interactions)
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Abstract

Influenza is a zoonotic respiratory disease of major public health interest due to its pandemic potential, and a threat to animals and the human population. The influenza A virus genome consists of eight single-stranded RNA segments sequestered within a protein capsid and a lipid bilayer envelope. During host cell entry, cellular cues contribute to viral conformational changes that promote critical events such as fusion with late endosomes, capsid uncoating and viral genome release into the cytosol. In this focused review, we concisely describe the virus infection cycle and highlight the recent findings of host cell pathways and cytosolic proteins that assist influenza uncoating during host cell entry.
Keywords: influenza; capsid uncoating; HDAC6; ubiquitin; EPS8; TNPO1; pandemic; M1; virus–host interaction influenza; capsid uncoating; HDAC6; ubiquitin; EPS8; TNPO1; pandemic; M1; virus–host interaction

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MDPI and ACS Style

Moreira, E.A.; Yamauchi, Y.; Matthias, P. How Influenza Virus Uses Host Cell Pathways during Uncoating. Cells 2021, 10, 1722. https://doi.org/10.3390/cells10071722

AMA Style

Moreira EA, Yamauchi Y, Matthias P. How Influenza Virus Uses Host Cell Pathways during Uncoating. Cells. 2021; 10(7):1722. https://doi.org/10.3390/cells10071722

Chicago/Turabian Style

Moreira, Etori Aguiar, Yohei Yamauchi, and Patrick Matthias. 2021. "How Influenza Virus Uses Host Cell Pathways during Uncoating" Cells 10, no. 7: 1722. https://doi.org/10.3390/cells10071722

APA Style

Moreira, E. A., Yamauchi, Y., & Matthias, P. (2021). How Influenza Virus Uses Host Cell Pathways during Uncoating. Cells, 10(7), 1722. https://doi.org/10.3390/cells10071722

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