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Review

Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord

by 1,* and 2,3,*
1
Experimental Surgery, Clinical and Translational Research Center, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece
2
Max Planck Institute for the Science of Light, 91058 Erlangen, Germany
3
Max-Planck-Zentrum für Physik und Medizin, 91058 Erlangen, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Antón Barreiro-Iglesias
Cells 2021, 10(6), 1404; https://doi.org/10.3390/cells10061404
Received: 29 April 2021 / Revised: 25 May 2021 / Accepted: 4 June 2021 / Published: 6 June 2021
(This article belongs to the Special Issue Axon Regeneration)
The capacity for long-distance axon regeneration and functional recovery after spinal cord injury is poor in mammals but remarkable in some vertebrates, including fish and salamanders. The cellular and molecular basis of this interspecies difference is beginning to emerge. This includes the identification of target cells that react to the injury and the cues directing their pro-regenerative responses. Among existing models of successful spinal cord regeneration, the zebrafish is arguably the most understood at a mechanistic level to date. Here, we review the spinal cord injury paradigms used in zebrafish, and summarize the breadth of neuron-intrinsic and -extrinsic factors that have been identified to play pivotal roles in the ability of zebrafish to regenerate central nervous system axons and recover function. View Full-Text
Keywords: zebrafish; spinal cord injury; axon regeneration; functional recovery zebrafish; spinal cord injury; axon regeneration; functional recovery
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MDPI and ACS Style

Tsata, V.; Wehner, D. Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord. Cells 2021, 10, 1404. https://doi.org/10.3390/cells10061404

AMA Style

Tsata V, Wehner D. Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord. Cells. 2021; 10(6):1404. https://doi.org/10.3390/cells10061404

Chicago/Turabian Style

Tsata, Vasiliki, and Daniel Wehner. 2021. "Know How to Regrow—Axon Regeneration in the Zebrafish Spinal Cord" Cells 10, no. 6: 1404. https://doi.org/10.3390/cells10061404

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