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Article

Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons

1
Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, TX 77807, USA
2
Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX 77807, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Antón Barreiro-Iglesias
Cells 2021, 10(7), 1625; https://doi.org/10.3390/cells10071625
Received: 14 May 2021 / Revised: 21 June 2021 / Accepted: 22 June 2021 / Published: 29 June 2021
(This article belongs to the Special Issue Axon Regeneration)
The age of incidence of spinal cord injury (SCI) and the average age of people living with SCI is continuously increasing. However, SCI is extensively modeled in young adult animals, hampering translation of research to clinical applications. While there has been significant progress in manipulating axon growth after injury, the impact of aging is still unknown. Mitochondria are essential to successful neurite and axon growth, while aging is associated with a decline in mitochondrial functions. Using isolation and culture of adult cortical neurons, we analyzed mitochondrial changes in 2-, 6-, 12- and 18-month-old mice. We observed reduced neurite growth in older neurons. Older neurons also showed dysfunctional respiration, reduced membrane potential, and altered mitochondrial membrane transport proteins; however, mitochondrial DNA (mtDNA) abundance and cellular ATP were increased. Taken together, these data suggest that dysfunctional mitochondria in older neurons may be associated with the age-dependent reduction in neurite growth. Both normal aging and traumatic injury are associated with mitochondrial dysfunction, posing a challenge for an aging SCI population as the two elements can combine to worsen injury outcomes. The results of this study highlight this as an area of great interest in CNS trauma. View Full-Text
Keywords: mitochondria; aging; neurite growth; dysfunction; mitochondrial respiration; CNS Injury mitochondria; aging; neurite growth; dysfunction; mitochondrial respiration; CNS Injury
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MDPI and ACS Style

Sutherland, T.C.; Sefiani, A.; Horvat, D.; Huntington, T.E.; Lei, Y.; West, A.P.; Geoffroy, C.G. Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons. Cells 2021, 10, 1625. https://doi.org/10.3390/cells10071625

AMA Style

Sutherland TC, Sefiani A, Horvat D, Huntington TE, Lei Y, West AP, Geoffroy CG. Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons. Cells. 2021; 10(7):1625. https://doi.org/10.3390/cells10071625

Chicago/Turabian Style

Sutherland, Theresa C., Arthur Sefiani, Darijana Horvat, Taylor E. Huntington, Yuanjiu Lei, A. Phillip West, and Cédric G. Geoffroy. 2021. "Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons" Cells 10, no. 7: 1625. https://doi.org/10.3390/cells10071625

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