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Pathogenesis of Endometriosis: The Origin of Pain and Subfertility

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Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Obstetrics, Augustenburger Platz 1, 13353 Berlin, Germany
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Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Endometriosis Centre Charité, Department of Gynaecology, Augustenburger Platz 1, 13353 Berlin, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Domenica Lorusso and Paola Piomboni
Cells 2021, 10(6), 1381; https://doi.org/10.3390/cells10061381
Received: 30 March 2021 / Revised: 24 May 2021 / Accepted: 27 May 2021 / Published: 3 June 2021
(This article belongs to the Special Issue Molecular and Cellular Aspects of Endometriosis)
Endometriosis (EM) and adenomyosis (AM) are common conditions with pain and infertility as the principal symptoms. The pathophysiology of pain in EM and AM comprises sensory and somatoform pain mechanisms. Over time, these may aggravate and lead to individual complex disease patterns if not diagnosed and treated. Despite the known facts, several years often pass between the onset of symptoms and diagnosis. Chronic pain disorders with changes on a neuronal level frequently arise and are linked to depressive disorders, with the process becoming a vicious cycle. Additionally, women with EM and AM suffer from sub- and infertility. Low fecundity rates are caused by anatomical changes in combination with behavioral changes in the sexual activity of women with chronic pain as well as local proinflammatory factors that not only decrease implantation rates but also promote early abortions. View Full-Text
Keywords: endometriosis; adenomyosis; pain; infertility; pathophysiology; inflammation; ovarian reserve endometriosis; adenomyosis; pain; infertility; pathophysiology; inflammation; ovarian reserve
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MDPI and ACS Style

Gruber, T.M.; Mechsner, S. Pathogenesis of Endometriosis: The Origin of Pain and Subfertility. Cells 2021, 10, 1381. https://doi.org/10.3390/cells10061381

AMA Style

Gruber TM, Mechsner S. Pathogenesis of Endometriosis: The Origin of Pain and Subfertility. Cells. 2021; 10(6):1381. https://doi.org/10.3390/cells10061381

Chicago/Turabian Style

Gruber, Teresa M., and Sylvia Mechsner. 2021. "Pathogenesis of Endometriosis: The Origin of Pain and Subfertility" Cells 10, no. 6: 1381. https://doi.org/10.3390/cells10061381

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