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The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines

1
Department of Molecular Neurochemistry, Faculty of Health Sciences, Medical University of Lodz, 92215 Lodz, Poland
2
Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China
*
Author to whom correspondence should be addressed.
Academic Editor: Vijaya Karoor
Cells 2021, 10(5), 1228; https://doi.org/10.3390/cells10051228
Received: 31 March 2021 / Revised: 12 May 2021 / Accepted: 14 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Role of GPCRs in Health and Disease)
Schizophrenia is a common debilitating disease characterized by continuous or relapsing episodes of psychosis. Although the molecular mechanisms underlying this psychiatric illness remain incompletely understood, a growing body of clinical, pharmacological, and genetic evidence suggests that G protein-coupled receptors (GPCRs) play a critical role in disease development, progression, and treatment. This pivotal role is further highlighted by the fact that GPCRs are the most common targets for antipsychotic drugs. The GPCRs activation evokes slow synaptic transmission through several downstream pathways, many of them engaging intracellular Ca2+ mobilization. Dysfunctions of the neurotransmitter systems involving the action of GPCRs in the frontal and limbic-related regions are likely to underly the complex picture that includes the whole spectrum of positive and negative schizophrenia symptoms. Therefore, the progress in our understanding of GPCRs function in the control of brain cognitive functions is expected to open new avenues for selective drug development. In this paper, we review and synthesize the recent data regarding the contribution of neurotransmitter-GPCRs signaling to schizophrenia symptomology. View Full-Text
Keywords: schizophrenia; G protein-coupled receptors; neurotransmitters; chemokines; calcium; drug development schizophrenia; G protein-coupled receptors; neurotransmitters; chemokines; calcium; drug development
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MDPI and ACS Style

Boczek, T.; Mackiewicz, J.; Sobolczyk, M.; Wawrzyniak, J.; Lisek, M.; Ferenc, B.; Guo, F.; Zylinska, L. The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines. Cells 2021, 10, 1228. https://doi.org/10.3390/cells10051228

AMA Style

Boczek T, Mackiewicz J, Sobolczyk M, Wawrzyniak J, Lisek M, Ferenc B, Guo F, Zylinska L. The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines. Cells. 2021; 10(5):1228. https://doi.org/10.3390/cells10051228

Chicago/Turabian Style

Boczek, Tomasz, Joanna Mackiewicz, Marta Sobolczyk, Julia Wawrzyniak, Malwina Lisek, Bozena Ferenc, Feng Guo, and Ludmila Zylinska. 2021. "The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines" Cells 10, no. 5: 1228. https://doi.org/10.3390/cells10051228

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