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Enhancing a Natural Killer: Modification of NK Cells for Cancer Immunotherapy

1
Cartherics Pty Ltd., Clayton 3168, Australia
2
Department of Obstetrics and Gynaecology, Monash University, Clayton 3168, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Subramaniam Malarkannan
Cells 2021, 10(5), 1058; https://doi.org/10.3390/cells10051058
Received: 1 April 2021 / Revised: 27 April 2021 / Accepted: 27 April 2021 / Published: 29 April 2021
(This article belongs to the Special Issue Allogeneic Cell Cancer Immunotherapies)
Natural killer (NK) cells are potent innate immune system effector lymphocytes armed with multiple mechanisms for killing cancer cells. Given the dynamic roles of NK cells in tumor surveillance, they are fast becoming a next-generation tool for adoptive immunotherapy. Many strategies are being employed to increase their number and improve their ability to overcome cancer resistance and the immunosuppressive tumor microenvironment. These include the use of cytokines and synthetic compounds to bolster propagation and killing capacity, targeting immune-function checkpoints, addition of chimeric antigen receptors (CARs) to provide cancer specificity and genetic ablation of inhibitory molecules. The next generation of NK cell products will ideally be readily available as an “off-the-shelf” product and stem cell derived to enable potentially unlimited supply. However, several considerations regarding NK cell source, genetic modification and scale up first need addressing. Understanding NK cell biology and interaction within specific tumor contexts will help identify necessary NK cell modifications and relevant choice of NK cell source. Further enhancement of manufacturing processes will allow for off-the-shelf NK cell immunotherapies to become key components of multifaceted therapeutic strategies for cancer. View Full-Text
Keywords: natural killer (NK) cells; pluripotent stem cells; allogeneic immunotherapy; cancer natural killer (NK) cells; pluripotent stem cells; allogeneic immunotherapy; cancer
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MDPI and ACS Style

Islam, R.; Pupovac, A.; Evtimov, V.; Boyd, N.; Shu, R.; Boyd, R.; Trounson, A. Enhancing a Natural Killer: Modification of NK Cells for Cancer Immunotherapy. Cells 2021, 10, 1058. https://doi.org/10.3390/cells10051058

AMA Style

Islam R, Pupovac A, Evtimov V, Boyd N, Shu R, Boyd R, Trounson A. Enhancing a Natural Killer: Modification of NK Cells for Cancer Immunotherapy. Cells. 2021; 10(5):1058. https://doi.org/10.3390/cells10051058

Chicago/Turabian Style

Islam, Rasa, Aleta Pupovac, Vera Evtimov, Nicholas Boyd, Runzhe Shu, Richard Boyd, and Alan Trounson. 2021. "Enhancing a Natural Killer: Modification of NK Cells for Cancer Immunotherapy" Cells 10, no. 5: 1058. https://doi.org/10.3390/cells10051058

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