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Review

Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome

1
Centre Nutrition, Santé et Société (NUTRISS), Institute of Nutrition and Functional Food (INAF), Université Laval, Québec, QC G1V 0A6, Canada
2
École de Nutrition, Faculté des Sciences de l’Agriculture et de l’Alimentation (FSAA), Université Laval, Québec, QC G1V 0A6, Canada
3
Canada Excellence Research Chair in Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), Université Laval, Quebec, QC G1V 4G5, Canada
4
Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Québec, QC G1V 4G5, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Alexander E. Kalyuzhny and Fabrizio Vincenzi
Cells 2021, 10(4), 938; https://doi.org/10.3390/cells10040938
Received: 8 February 2021 / Revised: 31 March 2021 / Accepted: 13 April 2021 / Published: 17 April 2021
Evidence suggesting the triangulation of the endocannabinoid system, exercise, and neurological health is emerging. In addition to the endocannabinoids N-arachidonoylethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG), the expanded endocannabinoid system, known as the endocannabinoidome (eCBome), appears to be an important player in this relationship. The eCBome includes several endocannabinoid-like mediators such as N-acylethanolamines and 2-monoacylglycerols, the enzymes involved in their biosynthesis and degradation, and the receptors they affect. This review aims to relate the functional interactions between aerobic exercise, and the molecular and cellular pathways related to endocannabinoids, in the hypothalamus, hippocampus, and the periphery, with special attention given to associations with emotional state, cognition, and mental health. Given the well-documented roles of many eCBome members in regulating stress and neurological processes, we posit that the eCBome is an important effector of exercise-induced central and peripheral adaptive mechanisms that benefit mental health. Gut microbiota imbalance, affecting the gut-brain axis and metabolism, also influences certain eCBome-modulated inflammation pathways. The integrity of the gut microbiota could thus be crucial in the onset of neuroinflammation and mental conditions. Further studies on how the modulation by exercise of the peripheral eCBome affects brain functions could reveal to be key elements in the prevention and treatment of neuropsychological disorders. View Full-Text
Keywords: stress; physical activity; endocannabinoids; microbiome; depression; mental health; peripheral nervous system; central nervous system; brain stress; physical activity; endocannabinoids; microbiome; depression; mental health; peripheral nervous system; central nervous system; brain
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MDPI and ACS Style

Forteza, F.; Giorgini, G.; Raymond, F. Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome. Cells 2021, 10, 938. https://doi.org/10.3390/cells10040938

AMA Style

Forteza F, Giorgini G, Raymond F. Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome. Cells. 2021; 10(4):938. https://doi.org/10.3390/cells10040938

Chicago/Turabian Style

Forteza, Fabiola, Giada Giorgini, and Frédéric Raymond. 2021. "Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome" Cells 10, no. 4: 938. https://doi.org/10.3390/cells10040938

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