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Review

The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation

Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli (NA), Italy
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Academic Editor: Hiroshi Miyamoto
Cells 2021, 10(3), 586; https://doi.org/10.3390/cells10030586
Received: 4 February 2021 / Revised: 26 February 2021 / Accepted: 3 March 2021 / Published: 7 March 2021
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the expression of a plethora of target genes involved in metabolism, immune reaction, cell differentiation, and a variety of other cellular changes and adaptive responses. PPARs are activated by a large number of both endogenous and exogenous lipid molecules, including phyto- and endo-cannabinoids, as well as endocannabinoid-like compounds. In this view, they can be considered an extension of the endocannabinoid system. Besides being directly activated by cannabinoids, PPARs are also indirectly modulated by receptors and enzymes regulating the activity and metabolism of endocannabinoids, and, vice versa, the expression of these receptors and enzymes may be regulated by PPARs. In this review, we provide an overview of the crosstalk between cannabinoids and PPARs, and the importance of their reciprocal regulation and modulation by common ligands, including those belonging to the extended endocannabinoid system (or “endocannabinoidome”) in the control of major physiological and pathophysiological functions. View Full-Text
Keywords: peroxisome proliferator-activated receptors (PPARs); endocannabinoid system (ECS); endocannabinoidome; plant cannabinoids; cannabinoid receptors; metabolism; neuroprotection peroxisome proliferator-activated receptors (PPARs); endocannabinoid system (ECS); endocannabinoidome; plant cannabinoids; cannabinoid receptors; metabolism; neuroprotection
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MDPI and ACS Style

Iannotti, F.A.; Vitale, R.M. The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation. Cells 2021, 10, 586. https://doi.org/10.3390/cells10030586

AMA Style

Iannotti FA, Vitale RM. The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation. Cells. 2021; 10(3):586. https://doi.org/10.3390/cells10030586

Chicago/Turabian Style

Iannotti, Fabio A., and Rosa M. Vitale. 2021. "The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation" Cells 10, no. 3: 586. https://doi.org/10.3390/cells10030586

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