A Systematic Review of MicroRNAs Involved in Cervical Cancer Progression
1
Molecular Oncology Research Center, Barretos Cancer Hospital, Teaching and Research Institute, Barretos-SP 14784-400, Brazil
2
Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo-SP 01246-000, Brazil
3
Gynecologic Oncology Department, Barretos Cancer Hospital, Barretos, São Paulo 14784-400, Brazil
4
Life and Health Sciences Research Institute (ICVS), Medical School, University of Minho, 4704-553 Braga, Portugal
5
ICVS/3B’s-PT Government Associate Laboratory, 4806-909 Braga/Guimarães, Portugal
6
Barretos School of Health Sciences, Dr. Paulo Prata–FACISB, Barretos, São Paulo 14785-002, Brazil
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work and share first authorship.
Cells 2021, 10(3), 668; https://doi.org/10.3390/cells10030668
Received: 13 February 2021
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Revised: 2 March 2021
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Accepted: 10 March 2021
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Published: 17 March 2021
(This article belongs to the Section Cellular Pathology)
To obtain a better understanding on the role of microRNAs in the progression of cervical cancer, a systematic review was performed to analyze cervical cancer microRNA studies. We provide an overview of the studies investigating microRNA expression in relation to cervical cancer (CC) progression, highlighting their common outcomes and target gene interactions according to the regulatory pathways. To achieve this, we systematically searched through PubMed MEDLINE, EMBASE, and Google Scholar for all articles between April 2010 and April 2020, in accordance with the PICO acronym (participants, interventions, comparisons, outcomes). From 27 published reports, totaling 1721 cases and 1361 noncancerous control tissue samples, 26 differentially expressed microRNAs (DEmiRNAs) were identified in different International Federation of Gynecology and Obstetrics (FIGO) stages of cervical cancer development. It was identified that some of the dysregulated microRNAs were associated with specific stages of cervical cancer development. The results indicated that DEmiRNAs in different stages of cervical cancer were functionally involved in several key hallmarks of cancer, such as evading growth suppressors, enabling replicative immortality, activation of invasion and metastasis, resisting cell death, and sustained proliferative signaling. These dysregulated microRNAs could play an important role in cervical cancer’s development. Some of the stage-specific microRNAs can also be used as biomarkers for cancer classification and monitoring the progression of cervical cancer.
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Keywords:
cervical cancer; microRNA; cervical cancer progression
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MDPI and ACS Style
Causin, R.L.; Freitas, A.J.A.d.; Trovo Hidalgo Filho, C.M.; Reis, R.d.; Reis, R.M.; Marques, M.M.C. A Systematic Review of MicroRNAs Involved in Cervical Cancer Progression. Cells 2021, 10, 668. https://doi.org/10.3390/cells10030668
AMA Style
Causin RL, Freitas AJAd, Trovo Hidalgo Filho CM, Reis Rd, Reis RM, Marques MMC. A Systematic Review of MicroRNAs Involved in Cervical Cancer Progression. Cells. 2021; 10(3):668. https://doi.org/10.3390/cells10030668
Chicago/Turabian StyleCausin, Rhafaela L., Ana J.A.d. Freitas, Cassio M. Trovo Hidalgo Filho, Ricardo d. Reis, Rui M. Reis, and Márcia M.C. Marques. 2021. "A Systematic Review of MicroRNAs Involved in Cervical Cancer Progression" Cells 10, no. 3: 668. https://doi.org/10.3390/cells10030668
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