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Growth Hormone and IGF1 Actions in Kidney Development and Function

1
Department of Nephrology, Schneider Children’s Medical Center of Israel, 14 Kaplan Street, Petach Tikva 4920235, Israel
2
Shraga Segal Department of Microbiology and Immunology, Ben Gurion University, Beer Sheva 8410501, Israel
3
Sackler School of Medicine, Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Haim Werner
Cells 2021, 10(12), 3371; https://doi.org/10.3390/cells10123371
Received: 12 September 2021 / Revised: 16 November 2021 / Accepted: 24 November 2021 / Published: 30 November 2021
(This article belongs to the Collection Insulin-Like Growth Factors in Development, Cancers and Aging)
Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1). The GH/IGF1 system plays a key role in normal kidney development, glomerular hemodynamic regulation, as well as tubular water, sodium, phosphate, and calcium handling. Transgenic animal models demonstrated that GH excess (and not IGF1) may lead to hyperfiltration, albuminuria, and glomerulosclerosis. GH and IGF-1 play a significant role in the early development of diabetic nephropathy, as well as in compensatory kidney hypertrophy after unilateral nephrectomy. Chronic kidney disease (CKD) and its complications in children are associated with alterations in the GH/IGF1 axis, including growth retardation, related to a GH-resistant state, attributed to impaired kidney postreceptor GH-signaling and chronic inflammation. This may explain the safety of prolonged rhGH-treatment of short stature in CKD. View Full-Text
Keywords: growth hormone; insulin-like growth factor 1; growth hormone receptor; receptor signaling; diabetic nephropathy; chronic kidney disease; kidney hypertrophy growth hormone; insulin-like growth factor 1; growth hormone receptor; receptor signaling; diabetic nephropathy; chronic kidney disease; kidney hypertrophy
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MDPI and ACS Style

Gurevich, E.; Segev, Y.; Landau, D. Growth Hormone and IGF1 Actions in Kidney Development and Function. Cells 2021, 10, 3371. https://doi.org/10.3390/cells10123371

AMA Style

Gurevich E, Segev Y, Landau D. Growth Hormone and IGF1 Actions in Kidney Development and Function. Cells. 2021; 10(12):3371. https://doi.org/10.3390/cells10123371

Chicago/Turabian Style

Gurevich, Evgenia, Yael Segev, and Daniel Landau. 2021. "Growth Hormone and IGF1 Actions in Kidney Development and Function" Cells 10, no. 12: 3371. https://doi.org/10.3390/cells10123371

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