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Review

The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth

Department of Pediatrics, Rutgers—Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
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Academic Editor: Haim Werner
Cells 2021, 10(10), 2664; https://doi.org/10.3390/cells10102664
Received: 23 August 2021 / Revised: 30 September 2021 / Accepted: 3 October 2021 / Published: 5 October 2021
(This article belongs to the Collection Insulin-Like Growth Factors in Development, Cancers and Aging)
In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master regulator of somatic development and involved, directly and indirectly, in carbohydrate and lipid metabolism via complex, yet well-defined, signaling pathways. GH production from the pituitary gland is primarily regulated by the counter-regulatory effects of the hypothalamic GHRH and SST hormones. The role of IGF-1 feedback regulation in GH production has been demonstrated by pharmacologic interventions and in genetically modified mouse models. In the present review, we discuss the role of IGF-1 in the regulation of the GH-axis as it controls somatic growth and metabolic homeostasis. We present genetically modified mouse models that maintain the integrity of the GH/GHRH-axis with the single exception of IGF-1 receptor (IGF-1R) deficiency in the hypothalamic GHRH neurons and somatotroph that reveals a novel mechanism controlling adipose tissues physiology and energy expenditure. View Full-Text
Keywords: IGF-1 singalling; growth hormone; GHRH; energy expenditure; adipose tissues physiology IGF-1 singalling; growth hormone; GHRH; energy expenditure; adipose tissues physiology
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MDPI and ACS Style

Al-Samerria, S.; Radovick, S. The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth. Cells 2021, 10, 2664. https://doi.org/10.3390/cells10102664

AMA Style

Al-Samerria S, Radovick S. The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth. Cells. 2021; 10(10):2664. https://doi.org/10.3390/cells10102664

Chicago/Turabian Style

Al-Samerria, Sarmed, and Sally Radovick. 2021. "The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth" Cells 10, no. 10: 2664. https://doi.org/10.3390/cells10102664

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