Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili, Dimitri; Rcheulishvili, Nino; Liu, Cong; Xie, Fengfei; Tyagi, Deependra; He, Yunjiao; Wang, Peng George

doi:10.3390/cells10112957

Open AccessReview

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

by

Dimitri Papukashvili

^†

,

Nino Rcheulishvili

^†

,

Cong Liu

,

Fengfei Xie

,

Deependra Tyagi

,

Yunjiao He

^* and

Peng George Wang

^*

School of Medicine, Southern University of Science and Technology, Shenzhen 518000, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Cells 2021, 10(11), 2957; https://doi.org/10.3390/cells10112957

Submission received: 10 October 2021 / Revised: 22 October 2021 / Accepted: 26 October 2021 / Published: 30 October 2021

(This article belongs to the Collection microRNAs in Health and Diseases)

Download

Browse Figures

Versions Notes

Abstract

Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.

Keywords: miRNA; AGA; DKK1; Wnt/β-catenin; hair

Share and Cite

MDPI and ACS Style

Papukashvili, D.; Rcheulishvili, N.; Liu, C.; Xie, F.; Tyagi, D.; He, Y.; Wang, P.G. Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy. Cells 2021, 10, 2957. https://doi.org/10.3390/cells10112957

AMA Style

Papukashvili D, Rcheulishvili N, Liu C, Xie F, Tyagi D, He Y, Wang PG. Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy. Cells. 2021; 10(11):2957. https://doi.org/10.3390/cells10112957

Chicago/Turabian Style

Papukashvili, Dimitri, Nino Rcheulishvili, Cong Liu, Fengfei Xie, Deependra Tyagi, Yunjiao He, and Peng George Wang. 2021. "Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy" Cells 10, no. 11: 2957. https://doi.org/10.3390/cells10112957

APA Style

Papukashvili, D., Rcheulishvili, N., Liu, C., Xie, F., Tyagi, D., He, Y., & Wang, P. G. (2021). Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy. Cells, 10(11), 2957. https://doi.org/10.3390/cells10112957

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI