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Modulation of Immune Components on Stem Cell and Dormancy in Cancer

Department of Oncology, Shengjing Hospital, China Medical University, Shenyang 110004, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Academic Editor: Ming Luo
Cells 2021, 10(11), 2826; https://doi.org/10.3390/cells10112826
Received: 29 August 2021 / Revised: 10 October 2021 / Accepted: 12 October 2021 / Published: 21 October 2021
(This article belongs to the Special Issue Targeting Cancer Stem Cell)
Cancer stem cells (CSCs) refer to a certain subpopulation within the tumor entity that is characterized by restricted cellular proliferation and multipotent differentiation potency. The existence of CSCs has been proven to contribute to the heterogeneity of malignancies, accounting for intensified tumorigenesis, treatment resistance, and metastatic spread. Dormancy was proposed as a reversible state of cancer cells that are temporarily arrested in the cell cycle, possessing several hallmarks that facilitate their survival within a devastating niche. This transient period is evoked to enter an actively proliferating state by multiple regulatory alterations, and one of the most significant and complex factors comes from local and systemic inflammatory reactions and immune components. Although CSCs and dormant cancer cells share several similarities, the clear relationship between these two concepts remains unclear. Thus, the detailed mechanism of immune cells interacting with CSCs and dormant cancer cells also warrants elucidation for prevention of cancer relapse and metastasis. In this review, we summarize recent findings and prospective studies on CSCs and cancer dormancy to conclude the relationship between these two concepts. Furthermore, we aim to outline the mechanism of immune components in interfering with CSCs and dormant cancer cells to provide a theoretical basis for the prevention of relapse and metastasis. View Full-Text
Keywords: cancer stem cell; dormancy; immune cell; intercellular communication; CSC niche cancer stem cell; dormancy; immune cell; intercellular communication; CSC niche
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MDPI and ACS Style

Jiang, X.; Liang, L.; Chen, G.; Liu, C. Modulation of Immune Components on Stem Cell and Dormancy in Cancer. Cells 2021, 10, 2826. https://doi.org/10.3390/cells10112826

AMA Style

Jiang X, Liang L, Chen G, Liu C. Modulation of Immune Components on Stem Cell and Dormancy in Cancer. Cells. 2021; 10(11):2826. https://doi.org/10.3390/cells10112826

Chicago/Turabian Style

Jiang, Xiaofan, Lu Liang, Guanglei Chen, and Caigang Liu. 2021. "Modulation of Immune Components on Stem Cell and Dormancy in Cancer" Cells 10, no. 11: 2826. https://doi.org/10.3390/cells10112826

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