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NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions

Department of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University, Sao Paulo 01049-010, Brazil
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Academic Editors: Junie P Warrington, Ana T. Palei, Mark W. Cunningham and Lorena M. Amaral
Cells 2021, 10(11), 2828; https://doi.org/10.3390/cells10112828
Received: 10 August 2021 / Revised: 14 October 2021 / Accepted: 15 October 2021 / Published: 21 October 2021
(This article belongs to the Special Issue The Pathophysiology of Preeclampsia and Eclampsia)
Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating different signaling patterns. One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Furthermore, reactive oxygen species (ROS), act as an intermediate to activate NLRP3, contributing to subsequent inflammatory cascades and cell damage. Moreover, increased production of ROS may elevate nitric oxide (NO) catabolism and consequently decrease NO bioavailability. NO has many roles in immune responses, including the regulation of signaling cascades. At the site of inflammation, vascular endothelium is crucial in the regulation of systemic inflammation with important implications for homeostasis. In this review, we present the important role of NLRP3 activation in exacerbating oxidative stress and endothelial dysfunction. Considering that the causes related to these processes and inflammation in PE remain a challenge for clinical practice, the use of drugs related to inhibition of the NLRP3 may be a good option for future solutions for this disease. View Full-Text
Keywords: NLRP3; preeclampsia; nitric oxide; endothelial dysfunction; oxidative stress; inflammation NLRP3; preeclampsia; nitric oxide; endothelial dysfunction; oxidative stress; inflammation
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MDPI and ACS Style

Nunes, P.R.; Mattioli, S.V.; Sandrim, V.C. NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions. Cells 2021, 10, 2828. https://doi.org/10.3390/cells10112828

AMA Style

Nunes PR, Mattioli SV, Sandrim VC. NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions. Cells. 2021; 10(11):2828. https://doi.org/10.3390/cells10112828

Chicago/Turabian Style

Nunes, Priscila R., Sarah V. Mattioli, and Valeria C. Sandrim 2021. "NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions" Cells 10, no. 11: 2828. https://doi.org/10.3390/cells10112828

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