Next Article in Journal
The Role of Epithelial Damage in the Pulmonary Immune Response
Next Article in Special Issue
Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview
Previous Article in Journal
Integrative Analysis to Identify Genes Associated with Stemness and Immune Infiltration in Glioblastoma
Previous Article in Special Issue
Inflammaging, an Imbalanced Immune Response That Needs to Be Restored for Cancer Prevention and Treatment in the Elderly
Review

Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions

1
Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA
2
Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA
3
Department Communication Sciences and Disorders, College of Behavioral & Communication Sciences, Tampa, FL 33620, USA
4
Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA
*
Author to whom correspondence should be addressed.
Equal First Authors.
Academic Editor: Alexander E. Kalyuzhny
Cells 2021, 10(10), 2761; https://doi.org/10.3390/cells10102761
Received: 14 September 2021 / Revised: 6 October 2021 / Accepted: 12 October 2021 / Published: 15 October 2021
(This article belongs to the Special Issue Inflammaging: The Immunology of Aging)
The slow accumulation of inflammatory biomarker levels in the body—also known as inflammaging—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson’s disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammaging has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating ion channels and mitochondrial involvement have shown promising relationships between their functions and inflammaging in the cochlea. In this review, we summarize key findings in inflammaging within the auditory system, the involvement of ion channels and mitochondrial functions, and lastly discuss potential treatment options focusing on controlling inflammation as we age. View Full-Text
Keywords: aging; inflammaging; auditory system; age-related hearing loss; cochlea aging; inflammaging; auditory system; age-related hearing loss; cochlea
Show Figures

Figure 1

MDPI and ACS Style

Bazard, P.; Pineros, J.; Frisina, R.D.; Bauer, M.A.; Acosta, A.A.; Paganella, L.R.; Borakiewicz, D.; Thivierge, M.; Mannering, F.L.; Zhu, X.; Ding, B. Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions. Cells 2021, 10, 2761. https://doi.org/10.3390/cells10102761

AMA Style

Bazard P, Pineros J, Frisina RD, Bauer MA, Acosta AA, Paganella LR, Borakiewicz D, Thivierge M, Mannering FL, Zhu X, Ding B. Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions. Cells. 2021; 10(10):2761. https://doi.org/10.3390/cells10102761

Chicago/Turabian Style

Bazard, Parveen, Jennifer Pineros, Robert D. Frisina, Mark A. Bauer, Alejandro A. Acosta, Lauren R. Paganella, Dominika Borakiewicz, Mark Thivierge, Freyda L. Mannering, Xiaoxia Zhu, and Bo Ding. 2021. "Cochlear Inflammaging in Relation to Ion Channels and Mitochondrial Functions" Cells 10, no. 10: 2761. https://doi.org/10.3390/cells10102761

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop